Agilent, 683975-914, InfinityLab Poroshell 120 SB-Aq, 4.6 x 150 mm, 2.7 µm

InfinityLab Poroshell 120 SB-Aq, 4.6 x 150 mm, 2.7 µm is designed for reversed-phase HPLC and UHPLC separation of polar and hydrophilic small molecules in highly aqueous mobile phases. The InfinityLab Poroshell 120 SB-Aq analytical column measures 4.6 mm in internal diameter and 150 mm in length, with 2.7 µm superficially porous silica particles and a 120 Å pore size. The SB-Aq alkyl reversed-phase chemistry is engineered to retain polar analytes even when the mobile phase contains a very high proportion of water, including 100% aqueous conditions. This helps address methods in which conventional hydrophobic phases give insufficient retention or lose reproducible wettability during prolonged aqueous operation. The stationary phase is not endcapped and operates within pH 1–8. Maximum operating temperature is 80 °C at pH 1–6 and 40 °C at pH 6–8, while the hardware pressure rating is 600 bar. The superficially porous particle format provides a short diffusion path that supports high-efficiency chromatography without requiring sub-2 µm particles. The column is supplied as a conventional analytical format and ships in acetonitrile/water. Applications include development and routine analysis of hydrophilic, polar compounds that require aqueous reversed-phase retention with the SB-Aq phase, rather than the selectivity of a typical C18 column.