Bio-Rad, AHP1124, SNAP-25 antibody

Name: SNAP-25 antibody
Brand: Bio-Rad
SKU: AHP1124

Size: 0.1 mg, Goat anti SNAP-25 (C-Terminal)

Catalog Number: AHP1124

Pricing

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Category

Polyclonal Antibodies

Pack Size0.1 mg

TagsProduct Types Polyclonal Antibody

Description

Goat ati Human SNAP25 antibody recognizes human synaptosomal-associated protein, 25kD (SNAP-25), also known as Super protein (Sup) or Synaptosomal-associated 25 kDa protein. SNAP-25 is a 206 amino acid, presynaptic plasma membrane protein containning 2 tSNARE coiled-coil domains and is essential for Ca2+-regulated exocytosis of neurotransmitters. SNAP-25 binds to and negatively modulate Ca2+ channels, increasing the speed of neurotransmitter release ( Rettiq et al. 1996 ) .Goat ati Human SNAP25 antibody detects an epitope within the C-terminal (CT) of human SNAP25 (aa 193-206). As a result of alternative splicing, SNAP-25 is expressed by neurons and neuroendocrine cells as two predominant isoforms; SNAP-25a and SNAP-25b. SNAP-25a is expressed early in development, whereas SNAP-25b expression is linked to synaptogenesis ( Bark and Wilson 1994 ). Goat ati human SNAP25 antibody is expected to recognise both isoforms. SNAP-25 may be a possible therapeutic treatment target for sufferers of hyperactivity disorders ( Barr et al. 2000 ), whilst SNAP-25 based peptides may be a possible treatment for involuntary muscle spasms ( Hodel 1998 ).

Storage Information
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

Specifications

General

Target Species	Human
Product Form	Purified IgG - liquid
Preservative Stabilisers	0.02% Sodium Azide 0.5% Bovine Serum Albumin
Immunogen	Peptide sequence C-DEANQRATKMLGSG corresponding to the C-terminus of SNAP-25 (NP_003072.2, NP_570824.1).
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
Product Type	Polyclonal Antibody
Isotype	Polyclonal IgG
Specificity	SNAP-25
Region	(C-TERMINAL)
Buffer Solution	TRIS buffered saline
Approx. Protein Concentrations	IgG concentration 0.5 mg/ml
UniProt	P60880
Entrez Gene	SNAP25
Synonyms	SYNAPTOSOMAL-ASSOCIATED Protein
RRID	AB_808741
Species Cross-Reactivity	Target Species Cross Reactivity Rat Expected from Sequence Mouse Dog Expected from Sequence
Antiserum Preparation	Antisera to human SNAP-25 were raised by repeated immunisations of goats with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.

Ordering

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