Bio-Rad, AHP1355, Muscarinic Receptor M3 antibody

Rabbit anti Human muscarinic receptor M3 antibody detects the muscarinic receptor M3, a G protein-coupled receptor for acetylcholine which is expressed in smooth muscle and glandular tissues. The M3 subtype is coupled to other G proteins known as G o or G q which activate phospholipase C leading to an increase in intracellular Ca 2+ . The M3 muscarinic receptor controls smooth muscle contraction in blood vessels and lungs as well as in the gastrointestinal tract. It is also located in many glands, and its activation helps to stimulate secretion. Mutations in the CHRM gene can lead to the development of Prune Belly Syndrome ( PBS ), a condition characterized by weak abdominal musculature, lax overlying skin, cryptorchism and urinary tract abnormalities ( Weber et al. 2011 ).

Storage Information
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.