Bio-Rad, AHP2662, p27/Kip1 (pThr187) antibody

Name: p27/Kip1 (pThr187) antibody
Brand: Bio-Rad
SKU: AHP2662

Size: 50 µl, Rabbit anti p27/Kip1 (pThr187)

Catalog Number: AHP2662

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Category

Polyclonal Antibodies

Pack Size50 µL

TagsProduct Types Polyclonal Antibody

Description

Rabbit anti p27/Kip1 (pThr187) antibody recognizes p27/Kip1, also known as cyclin-dependent kinase inhibitor p27 or cyclin-dependent kinase inhibitor 1B, when phosphorylated at threonine 187. p27/Kip1 is a cyclin-dependent kinase inhibitor (CKI) that belongs to the Cip/Kip protein family ( Cerqueira et al. 2014 ). p27/Kip1 inhibits cyclin-dependent kinases (CDKs) and cyclin-CDK complexes; playing a role in the regulation of cell cycle progression at G1 (Cerqueira et al. 2014). Phosphorylation of p27/Kip1 at threonine 187 by CDK2 leads to the ubiquitination and subsequent degradation of p27/Kip by the 26S proteosome ( Das et al. 2016 ).

Storage Information
This product is shipped at ambient temperature.
Store at -20°C
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

Specifications

General

Target Species	Human
Product Form	Purified IgG - liquid
Preservative Stabilisers	0.02% Sodium Azide 50% Glycerol
Immunogen	Phospho specific-peptide corresponding to residues surrounding threonine 187°F human p27/Kip1
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
Product Type	Polyclonal Antibody
Isotype	Polyclonal IgG
Specificity	p27/Kip1 (pThr187)
Buffer Solution	Phosphate buffered saline
UniProt	P46527
Entrez Gene	CDKN1B
GO Terms	GO:0000079 regulation of cyclin-dependent protein kinase activity
Species Cross-Reactivity	Target Species Cross Reactivity Mouse Expected from Sequence Rat Expected from Sequence
Antiserum Preparation	Antiserum to p27/Kip1 (pThr187) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.

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