Bio-Rad, HCA174, Alemtuzumab antibody | AbD16728

Name: Alemtuzumab antibody | AbD16728
Brand: Bio-Rad
SKU: HCA174

Size: 0.1 mg, Human anti Alemtuzumab

Catalog Number: HCA174

Pricing

Send an RFQ.

View RFQ List

Category

Monoclonal Antibodies

Pack Size0.1 mg

TagsProduct Types Monoclonal Antibody

Description

Human anti alemtuzumab antibody, clone AbD16728 recognizes alemtuzumab, a monoclonal antibody drug directed to human CD52 and used in the treatment of chronic lymphocytic leukemia (CLL), cutaneous T-cell lymphoma (CTCL) and T-cell lymphoma. Alemtuzumab is also used in some conditioning regimes for bone marrow transplantation, kidney transplantation and Islet cell transplantation along with clinical trial protocols for treatment of certain autoimmune diseases including multiple sclerosis. Human anti Alemtuzumab antibody, clone AbD16728 is an anti-idiotypic antibody that specifically recognizes the alemtuzumab humanized monoclonal antibody and and can be used to measure the levels of alemtuzumab and biosimilar products using bioanalytical assays. This antibody may be used in a bridging ELISA in conjunction with horseradish peroxidase conjugated clone AbD16942 ( HCA175P ). Clone AbD16728 has been demonstrated to inhibit the binding of alemtuzumab to CD52-positive human cells in flow cytometry. It also blocks the binding of clone YTH34.5, the Rat monoclonal prototype antibody of alemtuzumab, to CD52+ cells. View a summary of all anti-alemtuzumab antibodies .

Storage Information
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

Specifications

General

Acknowledgements
Product Form	A monovalent human recombinant Fab (lambda light chain) selected from the HuCAL phage display library, expressed in E.coli. The antibody is tagged with a V5 tag and a double extended Strep-tag. This antibody is supplied as a liquid.
Preservative Stabilisers	0.09% Sodium Azide (NaN 3 )
Immunogen	Alemtuzumab.
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
Product Type	Monoclonal Antibody
Clone	AbD16728
Isotype	HuCAL Fab monovalent
Specificity	Alemtuzumab
Preparation	StrepTactin affinity chromatography
Buffer Solution	Phosphate buffered saline
Approx. Protein Concentrations	Total protein concentration 0.5 mg/ml
Source	E.coli
RRID	AB_11152765
Affinity	The intrinsic affinity of the monovalent form of this antibody is K D =1.6 nM as measured by real time, label-free molecular interaction analysis on immobilized Alemtuzumab.

Ordering

Notice

Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
All quotations are subject to final confirmation, including product availability, lead time, batch information, shipping cost, and applicable export or handling requirements.
For quotation requests, please send an RFQ from website or contact:

[email protected]

Please send inquiries directly to us in the “To” field. Emails sent via BCC, mass mailing, or with unrelated recipients may be automatically filtered and will not be processed.