Bio-Rad, HCA203, Adalimumab antibody | AbD18654_hIgG1

Name: Adalimumab antibody | AbD18654_hIgG1
Brand: Bio-Rad
SKU: HCA203

Size: 0.1 mg, Human anti Adalimumab

Catalog Number: HCA203

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Category

Monoclonal Antibodies

Pack Size0.1 mg

TagsProduct Types Monoclonal Antibody

Description

Human Anti-Adalimumab Antibody, clone AbD18654_hIgG1 , is a high affinity anti-idiotypic antibody that specifically recognizes the adalimumab monoclonal antibody and inhibits the binding of adalimumab to its target, TNFα. The antibody can be used to measure the levels of adalimumab and biosimilar products in bioanalytical assays. Clone AbD18654_hIgG1 can be used to develop and calibrate immune response assays to measure the anti-drug antibody (ADA) response in patient serum. Adalimumab (branded as Humira) is a fully human monoclonal antibody (IgG1/kappa) approved for the treatment of ankylosing spondylitis, Crohn’s disease, psoriasis and several forms of arthritis. The antibody is specific for TNFα, and acts by blocking the activation of TNF receptors by TNFα. This inactivation down-regulates the inflammatory reactions associated with autoimmune diseases. View a summary of all Anti-Adalimumab Antibodies.

Storage Information
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

Specifications

General

Product Form	Human IgG1 antibody selected from the HuCAL phage display library and expressed in a human cell line. This antibody is supplied as a liquid.
Preservative Stabilisers	0.09% Sodium Azide (NaN 3 )
Immunogen	Adalimumab
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
Product Type	Monoclonal Antibody
Clone	AbD18654_hIgG1
Isotype	IgG1
Specificity	Adalimumab
Preparation	Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant.
Buffer Solution	Phosphate buffered saline
Approx. Protein Concentrations	HCA203G: Antibody concentration 1.0 mg/ml
Source	HKB-11
Synonyms	Humira
Affinity	The intrinsic affinity of the monovalent form of this antibody is K D =0.15 nM as measured by real time, label-free molecular interaction analysis on immobilized Adalimumab.
Acknowledgements	This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See bio-rad.com/en-us/trademarks for details. Humira is a trademark of Abbott Laboratories.

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