Bio-Rad, HCA386, Aflibercept antibody | AbD34644ia

Name: Aflibercept antibody | AbD34644ia
Brand: Bio-Rad
SKU: HCA386

Size: 0.1 mg, Human anti Aflibercept

Catalog Number: HCA386

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Category

Monoclonal Antibodies

Pack Size0.1 mg

TagsProduct Types Monoclonal Antibody

Description

Human Anti-Aflibercept Antibody, clone AbD34644ia is a recombinant antibody that specifically recognizes the fusion protein drug aflibercept as well as the vascular endothelial growth factor receptor 1 (VEGFR1). It does not recognize vascular endothelial growth factor receptor 2 (VEGFR2). The antibody binds to free aflibercept and can be used to measure free aflibercept or aflibercept biosimilars in patient samples. Clone AbD34644ia is a fully human recombinant monoclonal antibody with IgG1 isotype that can be used to develop a pharmacokinetic (PK) bridging assay to measure free drug. It is recommended as the detection antibody paired with the Human anti-Aflibercept Antibody, clone AbD38778da ( HCA390 ) as the capture reagent. Aflibercept (Eylea, Zaltrap) is a recombinant fusion protein consisting of the extra-cellular domain of human VEGF receptors 1 and 2, fused to the Fc portion of human IgG1. It is used to treat the 'wet' form of age-related macular degeneration (AMD) and impaired vision due to macular oedema. It is also used in the treatment of metastatic colorectal cancer in combination with 5-fluorouracil, leucovorin and irinotecan in patients previously treated with an oxaliplatin-containing chemotherapy. Aflibercept binds to circulating VEGF-A and VEGF-B to inhibit their ability to promote angiogenesis. View a summary of all anti aflibercept antibodies

Storage Information
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.

Specifications

General

Product Form	Human IgG1 antibody (kappa light chain) selected from the HuCAL phage display library and expressed in a human cell line. This antibody is supplied as a liquid.
Preservative Stabilisers	0.09% Sodium Azide (NaN 3 )
Immunogen	Aflibercept
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
Product Type	Monoclonal Antibody
Clone	AbD34644ia
Isotype	IgG1
Specificity	Aflibercept
Preparation	Purified IgG prepared by affinity chromatography on Protein A
Buffer Solution	Phosphate buffered saline
Approx. Protein Concentrations	Antibody concentration 0.5 mg/ml
Source	HKB-11
Synonyms	Eylea
Affinity	The intrinsic affinity of the monovalent form of Human anti Aflibercept antibody, clone AbD34644ia is K D = 11 nM as measured by real time, label free molecular interaction analysis on immobilized Aflibercept

Ordering

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