Bio-Rad, HCA388, Aflibercept antibody | AbD38771ia

Human Anti-Aflibercept Antibody, clone AbD38771ia is a recombinant antibody that specifically recognizes the fusion protein drug aflibercept at the region of the fusion of VEGFR with the Fc portion of human IgG1. It does not inhibit the binding of aflibercept to its target, the vascular endothelial growth factor (VEGF); it binds to both free aflibercept and aflibercept bound to its target VEGF and can be used to measure total aflibercept very specifically. Clone AbD38771ia is a fully human recombinant monoclonal antibody with IgG1 isotype that can be used to develop a pharmacokinetic (PK) bridging assay to measure total drug. It is recommended as the detection antibody paired with the Human anti-Aflibercept Antibody, clone AbD38720da ( HCA389 ) as the capture reagent. Aflibercept (Eylea, Zaltrap) is a recombinant fusion protein consisting of the extra-cellular domain of human VEGF receptors 1 and 2, fused to the Fc portion of human IgG1. It is used to treat the 'wet' form of age-related macular degeneration (AMD) and impaired vision due to macular oedema. It is also used in the treatment of metastatic colorectal cancer in combination with 5-fluorouracil, leucovorin and irinotecan in patients previously treated with an oxaliplatin-containing chemotherapy. Aflibercept binds to circulating VEGF-A and VEGF-B to inhibit their ability to promote angiogenesis. View a summary of all anti aflibercept antibodies

Storage Information
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.