Bio-Rad, MCA6307, AKT1 antibody | RM252

Rabbit anti Human Akt antibody recognizes RAC-alpha serine/threonine-protein kinase, also known as Protein Kinase B alpha, proto-oncogene c-Akt, RAC. The Akt family comprises three serine-threonine kinases, Akt1, Akt2, and Akt3, which play important roles in cell survival and proliferation ( Barnett et al. 2005 ). The PI3K/Akt signaling pathway is activated by growth factors, which in turn activates Akt1, and regulates cell survival during stress ( Hemmings and Restuccia et al. 2012 ). More specifically, Akt1 is activated by phosphorylation at serine 473 and threonine 308 ( Balasuriya et al. 2018 ). Transforming somatic mutations in Akt1 have been reported in a number of tumor types ( Jansen et al. 2017 ). Accordingly, Akt1 is an oncogene that is over-expressed in most human cancers, and is linked to poor survival. Inhibition of Akt1 is therefore of interest for cancer treatment ( Balasuriya et al. 2018 ).

Storage Information
Store at -20°C only.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use