Bio-Rad, TZA0142P, Aflibercept antibody | AbD38771pap

Name: Aflibercept antibody | AbD38771pap
Brand: Bio-Rad
SKU: TZA0142P

Size: 0.1 mg, Human anti Aflibercept:HRP

Catalog Number: TZA0142P

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Category

Monoclonal Antibodies

Pack Size0.1 mg

TagsProduct Types Monoclonal Antibody

Description

Human Anti-Aflibercept Antibody, clone AbD38771pap is a paratope specific, inhibitory antibody that specifically recognizes the free fusion protein drug aflibercept as well as the vascular endothelial growth factor receptor 1 (VEGFR1) but not the vascular endothelial growth factor receptor 2 (VEGFR2). It does not recognize free VEGF nor aflibercept in complex with VEGFR. TZA0142P, clone AbD38771pap is a bivalent Fab antibody already conjugated to HRP via coupling to the HRP conjugated BiSpyCatcher2 ( TZC002P ) for use in direct ELISA. A pair of anti-aflibercept antibodies can be used to develop a pharmacokinetic (PK) bridging assay to measure free drug. Clone AbD38771pap is recommended as the detection antibody, paired with Human Anti-Aflibercept Antibody in monovalent Fab format, clone AbD38720da ( HCA389 ) as the capture antibody. Aflibercept (Eylea, Zaltrap) is a recombinant fusion protein consisting of the extra-cellular domain of human VEGF receptors 1 and 2, fused to the Fc portion of human IgG1. It is used to treat the 'wet' form of age-related macular degeneration (AMD) and impaired vision due to macular oedema. It is also used in the treatment of metastatic colorectal cancer in combination with 5-fluorouracil, leucovorin and irinotecan in patients previously treated with an oxaliplatin-containing chemotherapy. Aflibercept binds to circulating VEGF-A and VEGF-B to inhibit their ability to promote angiogenesis. View a summary of all anti aflibercept antibodies

Storage Information
This product is shipped frozen.
When ready to use, thaw and aliquot the sample as needed. Store aliquots at -70°C, if available, otherwise store at -20°C. It is not recommended to keep aliquots at 4°C for more than one week

Specifications

General

Product Form	A bivalent human recombinant Fab (lambda light chain) generated by coupling of the monovalent SpyTagged Fab with a HRP conjugated BiSpyCatcher version 2 ( TZC002P ). The coupled antibody has two DYKDDDDK tags and three His6-tags. It contains SpyTag3 peptide ( BLP086 ) in 5-fold molar excess to block any unreacted Catcher sites. This antibody is supplied as a liquid.
Preservative Stabilisers	0.0095% MIT
Immunogen	Aflibercept
Regulatory	For research purposes only
Guarantee	12 months from date of despatch
Product Type	Monoclonal Antibody
Clone	AbD38771pap
Isotype	Fab antibody
Specificity	Aflibercept
Preparation	Metal chelate affinity chromatography
Buffer Solution	Phosphate buffered saline
Approx. Protein Concentrations	Antibody concentration 0.5 mg/ml
Source	E.coli
Synonyms	Eylea
Affinity	The intrinsic affinity of the monovalent form of Human anti Aflibercept antibody, clone AbD38771pap is K D = 124 nM as measured by real time, label free molecular interaction analysis on immobilized Aflibercept

Ordering

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