Bio-Rad, VMA00253, AKT1 antibody | OTI4C11

Mouse anti Human AKT1 antibody recognizes the RAC-alpha serine/threonine-protein kinase, also known as AKT1m, PKB alpha, RAC-PK-alpha, protein kinase B alpha, proto-oncogene c-Akt and rac protein kinase alpha. The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in AKT1 have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for AKT1 (provided by RefSeq, Jul 2011). Mouse anti Human AKT1 antibody detects a band of 60 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.

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Store undiluted at -20°C, avoiding repeated freeze thaw cycles.