Description
Product Usage Information
Western Blotting: 1:1000
Immunoprecipitation: 1:50
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.
Protocol
Available protocols: Western Blotting, Immunoprecipitation
Specificity / Sensitivity
APBA2 (D8A6) Rabbit Monoclonal Antibody recognizes endogenous levels of total APBA2 protein.
Species Reactivity: Human, Mouse, Rat
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val23 of human APBA2 protein.
Background
Amyloid β A4 precursor protein-binding family A member 2 (APBA2) is a neuronal adaptor protein that interacts with the amyloid β precursor protein (APP) (1). The amyloid β-protein (Aβ) is the principal component of amyloid plaques, a pathological hallmark of Alzheimer's disease (2). APBA2 has been shown to stabilize APP metabolism and suppress the secretion of Aβ (3). APBA2 mediates interaction between APP and the neural type I membrane protein Alcadein (Alc) by linking their cytoplasmic domains, thereby forming a tripartite complex of the three proteins in neurons (4).
Alternate Names
Adapter protein X11beta; amyloid beta (A4) precursor protein-binding, family A, member 2; amyloid beta (A4) precursor protein-binding, family A, member 2 (X11-like); Amyloid beta A4 precursor protein-binding family A member 2; amyloid beta precursor protein binding family A member 2; Amyloid-beta A4 precursor protein-binding family A member 2; APBA2; D15S1518E; HsT16821; LIN-10; MGC:14091; MGC99508; Mint-2; MINT2; Neuron-specific X11L protein; Neuronal Munc18-1-interacting protein 2; phosphotyrosine-binding/-interacting domain (PTB)-bearing protein; X11-BETA; X11-like protein; X11L
