CST, 18818S, ALDH2 Antibody

Product Usage Information
Western Blotting: 1:1000
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.
Protocol
Available protocols: Western Blotting
Specificity / Sensitivity
ALDH2 Antibody recognizes endogenous levels of total ALDH2 protein.
Species Reactivity: Human
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val348 of human ALDH2 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background
Aldehyde dehydrogenase 2 (ALDH2) is a member of the ALDH superfamily (1). The enzymes in this family catalyze the oxidation of various aldehydes, thereby facilitating their detoxification (1,2). ALDH2 activation correlates with decreased ischemic heart injury, suggesting an essential role of ALDH2 in cardiac protection from ischemic injury (3). Additionally, ALDH2 is the primary enzyme responsible for aldehyde oxidation in hematopoietic stem cells (4). ALDH2 is required for protecting these cells from DNA damage caused by acetaldehyde and plays a critical role in counteracting genotoxicity (4,5). Promoting ALDH2 activity in the brain attenuates neuroinflammation and may improve cognitive function, making this enzyme a therapeutic target for neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD) (6-9).
Alternate Names
acetaldehyde dehydrogenase 2; aldehyde dehydrogenase 2 family (mitochondrial); aldehyde dehydrogenase 2 family member; Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDH2; ALDHI; ALDM; epididymis secretory sperm binding protein; liver mitochondrial ALDH; MGC1806; nucleus-encoded mitochondrial aldehyde dehydrogenase 2