CST, 31443S, Alectinib

Product Usage Information
Alectinib is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.04 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Storage
Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Background
Alectinib (CH5424802) is a potent, selective ALK inhibitor with an IC value of 1.9 nM. In addition to blocking phosphorylation of native ALK, it also blocks phosphorylation of ALK mutant strands L1196M, F1174L, R1275Q, and C1156Y (1,2). L1196M is found in tumor cells of patients with non-small cell lung cancer (NSCLC). Alectinib has been shown to have antitumor activity in mouse xenograft models of NSCLC by inhibiting tumor growth via suppression of cell growth and apoptosis (1).
Alternate Names
9-Ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5H-benzo[b]carbazole-3- carbonitrile; CH5424802; RO5424802