CST, 44462S, PTMScan ® Nitro-Tyrosine Motif [Nitro-Y] Kit

Storage
Antibody beads supplied in IAP buffer containing 50% glycerol. Store at -20°C. Do not aliquot the antibody.
Protocol
Available protocols: PTMScan
Background
Nitric oxide (NO) is implicated in carcinogenesis (1), chronic infection, inflammation (2), and neurodegeneration (3). High levels of both superoxide and NO in tissues interact to form peroxynitrite, a potent oxidant that can modify Tyr residues in proteins to form 3-nitro-tyrosine (4). Tyrosine nitration of mitochondrial manganese superoxide dismutase results in loss of enzymatic activity (4). The nitration of p53 at Tyr residues abolishes its capacity for binding to its DNA consensus sequence (5).
Alternate Names
3-nitrotyrosine; 3NT; Nitro-Y; Nitrosylation; nitrotyrosine; NO2Y; Tyrosine nitration; Y-NO2