CST, 49079S, Verapamil (Hydrochloride)

Product Usage Information
Verapamil (Hydrochloride) is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.02 ml of water. Working concentrations and length of treatment can vary depending on the desired effect.
Storage
Store lyophilized at room temperature, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Background
Verapamil (Hydrochloride) is a phenylalkylamine racemic mixture that inhibits the influx of extracellular calcium ions into myocardial and vascular smooth muscle cells by blocking L-type calcium channels and is commonly used in the treatment of high blood pressure, angina, and heart arrhythmias (1). Research has shown that Ca channel blockers, such as Verapamil (Hydrochloride), can mediate Influenza A viral entry into cells (2). Studies have also shown Verapamil (Hydrochloride) to be an inhibitor of drug efflux pump proteins, such as P-glycoprotein, resulting in the reversal of multidrug resistance by tumor cells (3). As an L-type calcium channel antagonist, Verapamil (Hydrochloride) effectively inhibits Ebolaviruses (EBOV) infection with an IC value of 4 μM (4).
Alternate Names
Verapamil; α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1- methylethyl)benzeneacetonitrile, hydrochloride