CST, 51854S, Mitomycin C

Product Usage Information
Mitomycin C is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 997 μl of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Storage
Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Background
Mitomycin C, also known as MMC, is an antitumor antibiotic isolated from (1). When activated, this alkylating agent crosslinks double stranded DNA resulting in DNA damage (2). Mitomycin C has been found to have lethal effects on HeLa cells during the G phase of the cell cycle (3). DNA damage caused by Mitomycin C can lead to increased levels of that can result in cell cycle arrest or apoptosis (4).
Alternate Names
[1aS-(1aα,8β,8aα,8bα)]-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione; Ametycine; Fermentation product from Streptomyces sp.; MitoExtra; Mitonco; Mitoplus; MMC; NSC 26980; Streptomyces sp.