CST, 59732S, Mouse IL-13 Recombinant Protein

Storage
Mouse IL-13 Recombinant Protein is supplied as lyophilized material that is very stable at -20ºC. It is recommended to reconstitute with sterile 20 mM HCl at a concentration of 0.1 mg/mL which can be further diluted as needed. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Once in solution, store at 4ºC and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles if storing reconstituted material at -20ºC to -80ºC.
Source / Purification
Recombinant mouse IL-13 was expressed in genetically modified and is supplied in a lyophilized form.
Background
Interleukin-13 (IL-13) is produced by T cells and is important in the Th2 response. IL-13 targets include B cells, eosinophils, fibroblasts, mast cells, and macrophages (1-3). IL-13 binds specifically to IL-13Rα1 that complexes with IL-4Rα to form the type II IL-4R. Jak1 and Tyk2 are activated and signal through Stat3 and Stat6 (4). IL-13Rα2 is a different gene product; it lacks the intracellular domain, does not complex with IL-4Rα, and does not signal (1,4,5). The extracellular domain of IL-13Rα2 is often elevated in diseased states. IL-13 plays a key role in airway hyperresponsiveness (AHR) of allergic asthma (1,6,7) and modulates resistance to parasitic organisms (1).
Alternate Names
il13; IL13; NC30; T-cell activation protein P600