CST, 64430S, ABAT Antibody

Product Usage Information
Western Blotting: 1:1000
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, and 50% glycerol. Store at -20°C. Do not aliquot the antibody.
Protocol
Available protocols: Western Blotting
Specificity / Sensitivity
ABAT Antibody recognizes endogenous levels of total ABAT protein.
Species Reactivity: Human, Mouse, Rat
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly43 of human ABAT protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background
4-aminobutyrate aminotransferase (ABAT) is an enzyme localized within the mitochondrial matrix that acts to catabolize γ-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the central nervous system. ABAT deficiency leads to elevated GABA levels and is associated with a variety of neurological afflictions, including mood and cognitive disorders, psychomotor retardation, and seizures (1,2). Genetic variants of ABAT have also been linked to Alzheimer's disease (3). In addition to the neurological implications, dysregulation of GABA as a consequence of ABAT deficiency has been linked to the pathogenesis of breast and liver cancers (4-6). Collectively, these studies suggest that ABAT may be a therapeutic target for both neurological disorders and some forms of cancer.
Alternate Names
(S)-3-amino-2-methylpropionate transaminase; 4-aminobutyrate aminotransferase; 4-aminobutyrate aminotransferase, mitochondrial; 4-aminobutyrate transaminase; ABAT; FLJ17813; GABA aminotransferase; GABA transaminase; GABA transferase; GABA-AT; GABA-T; GABAT; GABT; Gamma-amino-N-butyrate transaminase; gamma-aminobutyrate aminotransferase; L-AIBAT; NPD009