CST, 65650S, Arg3.1 (D6H9N) Rabbit Monoclonal Antibody

Product Usage Information
Western Blotting: 1:1000
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.
Protocol
Available protocols: Western Blotting
Specificity / Sensitivity
Arg3.1 (D6H9N) Rabbit Monoclonal Antibody recognizes endogenous levels of total Arg3.1 protein. A band of unknown origin is detected ~40kDa in some rodent samples.
Species Reactivity: Human, Mouse, Rat
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val209 of human Arg3.1 protein.
Background
Arg3.1, also known as Arc for activity-regulated cytoskeleton-associated protein, is an immediate early gene whose expression is necessary for synaptic plasticity (1). Arg3.1 expression is induced by many experimental stimuli such as LTP (2), LTD (3), and learning. Arg3.1 is also involved in the regulation of synaptic strength and homeostatic scaling by promoting AMPA receptors endocytosis (5,6). Arg3.1 dysregulation has been proposed to participate in cognitive decline during aging (7).
Alternate Names
activity regulated cytoskeleton associated protein; Activity-regulated cytoskeleton-associated protein; Activity-regulated gene 3.1 protein homolog; ARC; ARC/ARG3.1; Arg3.1; hArc; KIAA0278