CST, 68998S, U-18666A

Product Usage Information
U-18666A is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.17 ml of water. Working concentrations and length of treatment can vary depending on the desired effect.
Storage
Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Background
U-18666A is a cell permeable drug that inhibits cholesterol transport. This small molecule inhibits low density lipoprotein (LDL)-derived cholesterol transport, blocking cholesterol esterification, and suppressing LDL receptor activities (1). Studies have shown that impaired cholesterol trafficking is associated with neurological diseases such as Alzheimer's disease (AD), Niemann-Pick disease type C (NPC), and atherosclerosis (2,3). The mechanisms of neurodegeneration for these diseases are mostly unknown so studies using U-18666A to simulate intracellular cholesterol accumulation may provide greater insight into these pathologies (2). Cholesterol levels play a role in the body's response to viral infection and the ability of a virus to enter and replicate within a host cell, making U-18666A an important compound when studying different viral diseases (4).
Alternate Names
(3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one, hydrochloride; U-18666A hydrochloride; U18666A; U18666A hydrochloride