CST, 80577S, Talazoparib

Product Usage Information
Talazoparib is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.31 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Storage
Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Background
Talazoparib (BMN 673) is a potent, selective PARP inhibitor with an IC value for PARP1 of 0.57 nM. It can inhibit both PARP1 and PARP2, but not PARG. Talazoparib selectively targets tumor cells with , , and gene mutations. It is effective in inducing antitumor activity in xenografted tumors from mice (1).
Alternate Names
(8S,9R)-5-fluoro-8-(4-fluorophenyl)-2,7,8,9-tetrahydro-9-(1-methyl-1H-1,2,4-triazol-5-yl)-3Hpyrido[ 4,3,2-de]phthalazin-3-one; BMN673