CST, 89422S, Human FGF-10 Recombinant Protein

Storage
Human FGF-10 Recombinant Protein is supplied as lyophilized material that is very stable at -20°C. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg/mL which can be further diluted in aqueous solutions as needed. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Once in solution, store at 4°C and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles if storing reconstituted material at -20ºC to -80ºC.
Source / Purification
Recombinant human FGF-10 was expressed in and is supplied in a lyophilized form.
Background
FGF-10 is a member of the large and diverse fibroblast growth factor (FGF) family of peptide growth factors. FGF-10 functions as a signaling molecule that is involved in many important processes (1,2). It binds to receptor FGFR2b and is essential as a signaling growth factor for mesenchymal-to-epithelial transition (3). FGF-10 is involved in limb development and morphogenesis of multiple organs, such as lung, skin, ear, and salivary gland (3,4). Knockout mice for FGF-10 show severe phenotypes with complete truncation of the fore- and hindlimbs and they die shortly after birth due to impaired lung development (4).