CST, 90126S, GSK872

Product Usage Information
GSK872 is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.30 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.
Storage
Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Background
GSK872 is a potent, selective inhibitor of RIP3 with an IC value of 1.8 nM and inhibits kinase activity with an IC value of 1.3 nM (1,2). RIP3 is required for necroptosis (3). When this compound is tested at 1 µM, it shows >1,000-fold specificity for RIP3 compared with over 300 kinases tested (1). GSK872 inhibits both virus-, TNF- and TLR-3-induced necrosis in fibroblasts (1).
Alternate Names
GSK2399872A; N-(6-Propan-2-ylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amine