Description
Product Usage Information
Western Blotting: 1:1000
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.
Protocol
Available protocols: Western Blotting
Specificity / Sensitivity
APMAP (F1E6M) Rabbit Monoclonal Antibody recognizes endogenous levels of total APMAP protein. This antibody detects a 95 kDa band of unknown origin.
Species Reactivity: Human, Mouse, Rat
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly170 of mouse APMAP protein.
Background
APMAP (Adipocyte plasma membrane-associated protein, DD16, C20orf3) is a glycosyl-type II transmembrane protein mainly distributed in the plasma membrane and endoplasmic reticulum of adipocytes (1-5). APMAP is induced during adipocyte differentiation and has been reported to have roles in fat differentiation, cancer development, viral infections, and Alzheimer's disease (3,4). APMAP has been identified as a factor that impedes antibody-dependent cellular phagocytosis (ADCP), with loss of APMAP leading to slower tumor growth and sensitizing of cancer cells to phagocytosis (5).
Alternate Names
2310001A20Rik; adipocyte plasma membrane associated protein; Adipocyte plasma membrane-associated protein; AI314817; Apmap; OTTMUSP00000016748; Protein DD16; RIKEN cDNA 2310001A20 gene
