Description
Protocol
Available protocols: ELISA+
Specificity / Sensitivity
The FastScan™ Total Neurogranin ELISA Kit detects endogenous levels of neurogranin, as shown in Figure 1. This kit detects proteins from the indicated species, as determined through in-house testing, but may also detect homologous proteins from other species.
Species Reactivity: Human, Mouse, Rat
Background
Neurogranin is a small neuronal protein that binds to calmodulin in the absence of Ca (1,2). Calmodulin binds Ca and acts as a Ca sensor to drive Ca -dependent signal transduction pathways by modulating its interaction with various kinases and phosphatases (3). In the postsynaptic compartment of the neuron, Ca  is carefully regulated and is a critical regulator of synaptic function and plasticity (4). Neurogranin is primarily expressed in the brain and is enriched in somato-dendritic compartments of projection neurons in various regions of the brain (5). Postsynaptically-enriched neurogranin likely influences Ca  or Ca /calmodulin-dependent neuronal functions, including synaptic plasticity, by binding to and releasing calmodulin in a Ca -dependent manner (6-9). Genetic variants in the gene encoding neurogranin, are linked to several neuropsychiatric diseases, including schizophrenia (10). Interestingly, increase in cerebrospinal fluid neurogranin is correlated with neurodegenerative disease progression, which suggests that neurogranin could act as a biomarker for diseases like Alzheimer's disease (11).
Alternate Names
calmodulin-binding protein; hng; NEUG; NEUG(55-78); Neurogranin; neurogranin (protein kinase C substrate, RC3); Ng; NRGN; protein kinase C substrate; RC3
