Cytiva, 17542053, HiTrap™ MabSelect™ VL 1 × 5 mL

Built for a diversifying pipeline As the diversity of antibody variants increases, so does the need for chromatography resins that can capture and purify these variants. As an alternative to protein A, protein L can be used to capture antibody Fabs, bispecific antibodies, and other molecules containing kappa variants of the variable light (VL) chain. Protein L binds human kappa light chain subtypes 1, 3, and 4 and mouse kappa light chain subtype 1. Redesigned protein L ligand We observed a two-fold increase in binding capacity of MabSelect™ VL resin compared to our Capto™ L chromatography resin and HiTrap™ Protein L columns . This higher capacity provides productivity advantages in research and biomanufacturing. The MabSelect™ VL resin can withstand cleaning with 0.1 M NaOH, thanks to multimerization and modification of one of the domains of the native protein L ligand. MabSelect™ VL protein L resin is also available as bulk resins in different pack sizes, PreDictor™ RoboColumn® minicolumns , ReadyToProcess™ columns . Contact your Cytiva sales representative for more information.