Cytiva, 17542402, MabSelect™ SuRe 70 protein A resin, 200 mL

MabSelect™ SuRe 70 protein A resin with high dynamic binding capacity (DBC), enables highly cost-efficient capture of monoclonal antibodies (mAbs). The resin uses the well-established SuRe protein A ligand with good alkaline stability providing stable processing of mAbs.
Cost-efficient at low resin utilization, such as in clinical manufacturing.
Highest DBC of any of our MabSelect SuRe™ resins
Alkaline-stable, well-established protein A ligand, from the MabSelect SuRe resin, is stable when cleaned with 0.1 M NaOH for 200 cycles and approximately 100 cycles using 0.5 M NaOH.
Excellent for use in short bed heights and rapid resin cycling mode to further improve productivity in protein A step.
DBC at different residence times
The MabSelect™ SuRe 70 resin is based on a high-flow agarose base matrix with an average bead size of 50 μm. The optimized porosity enables a fast uptake of mAb, and the DBC is less dependent on residence time (RT) compared to other resins (e.g., MabSelect SuRe™ LX and MabSelect PrismA™ resins). The DBC for trastuzumab is higher than 70 g/L in a well-packed column at 6 min RT.
Alkaline-stable protein A ligand
As native protein A is sensitive to alkaline conditions, the ligand in MabSelect™ SuRe 70 resin, also used in the MabSelect SuRe™ resin, has been stabilized by engineering one of the IgG-binding domains of protein A. The MabSelect™ SuRe 70 resin is stable when cleaned with 0.1 M NaOH for 200 cycles and approximately 100 cycles using 0.5 M NaOH without performance loss.
Formats
MabSelect™ SuRe 70 resin is available as bulk resin in 25 mL, 200 mL, 1 L, 5 L, and 10 L containers. The resin can be ordered in pre-packed column formats such as HiTrap™ columns (1 and 5 mL), HiScreen™ columns, and on request as production scale ReadyToProcess™ columns. These formats enable use from lab-scale to commercial-scale manufacturing.
Cytiva’s mAb toolbox
Process volumes, number of batches, target molecule, impurity profile, and cleaning protocols influence which chromatography resin will be most cost-efficient and productive in a given application. Cytiva can support you in a discussion about how to set up your process and to make your process more cost efficient. And with every Cytiva resin you choose, you have Cytiva quality, an extensive security of supply program, and expertise to go along with it. Contact us for a productivity discussion .