Cytiva, 17543803, MabSelect SuRe, 1 L

Name: MabSelect SuRe, 1 L
Brand: Cytiva
SKU: 17543803

Novel, alkali-stabilized protein A ligand allows the use of 0.1–0.5 M sodium hydroxide for cleaning-in-place (CIP).

Catalog Number: 17543803

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Category

Mixed-Mode Resins

Pack Size1 L

TagsChromatography resins Chromatography products Affinity antibody resin

CollectionsCytiva Chromatography Columns, Resins & Lab Glassware Cytiva Protein Analysis Equipment & Supplies Collection

Description

The recombinant protein A ligand of Cyitva's MabSelect SuRe ™ has been engineered to withstand 0.1–0.5 M NaOH, enabling efficient cleaning of the chromatography resin.
In process-scale applications, this NaOH tolerance extends the lifetime of the resin and allows for the use of rigorous and cost-effective CIP and sanitization protocols.
In research applications, this NaOH tolerance enables the purification of multiple antibody types with minimized cross-contamination risk.
Protein ligand designed for enhanced protease resistance compared with unmodified protein A leads to lower ligand leakage.
Meets industrial demands in terms of comprehensive technical and regulatory support and security of supply.
Animal-component free raw materials and manufacturing process.
MabSelect SuRe resin properties
This resin for monoclonal antibody (mAb) purification contains a rigid, high-flow agarose matrix that delivers excellent pressure/flow properties. Like many of Cytiva's protein A chromatography resins, MabSelect SuRe™ uses oriented ligand coupling for excellent binding capacity. It exhibits low nonspecific protein binding, thereby decreasing impurity levels in the eluate pool.
Benefits of alkali-tolerant protein A ligand
MabSelect SuRe™ resin features an engineered, alkali-tolerant rProtein A ligand for mAb purification. The ligand provides greater stability than conventional protein A affinity resins in the alkaline conditions used in cleaning-in-place (CIP) and sanitization protocols. The resin can withstand rigorous CIP and sanitization procedures with 0.1 to 0.5 M NaOH. The enhanced alkali stability of this resin improves process economy and product quality; cleaning can be performed with cost-effective reagents such as sodium hydroxide, eliminating the need for expensive and hazardous cleaning agents such as Gua-HCl.
Generic elution conditions for different mAbs
MabSelect SuRe™ resin offers generic elution conditions for different monoclonal antibodies, which is an advantage when designing purification platform processes. This feature is also correlated to the construction of the rProtein A ligand, which has a reduced interaction with the VH3 (Fab) domain present in human antibodies.
Compatible empty columns – bioprocess scale
For process-scale applications, Cytiva recommends AxiChrom™ chromatography columns for the MabSelect™ family of products.
Convenient prepacked columns – research scale
This chromatography resin is also available in the following formats:
HiTrap™ MabSelect SuRe™: convenient for easy use with a syringe, peristaltic pump, and chromatography system
HiScreen™ MabSelect SuRe™ for method and process development
PreDictor™ MabSelect SuRe™ 96-well filter plate for high-throughput screening or process development
PredDictor™ RoboColumns MabSelect™– miniaturized column format for high-throughput process development
Convenient prepacked columns – bioprocess scale
Prepacked ReadyToProcess™ columns are available, eliminating the need for column packing and cleaning validation.
Learn about prepacked HiScreen MabSelect SuRe , HiTrap MabSelect SuRe , ReadyToProcess MabSelect SuRe columns , PreDictor MabSelect SuRe or PreDictor Robocolumns MabSelect SuRe

Specifications

General

Chromatography technique	Antibody affinity chromatography
Binding Capacity/ml Chromatography Medium	Approx. 35 mg human lgG/mL at 2.4 min residence time
BioProcess resin	Yes
Certificate of Analysis	Yes
Chemical stability	Stable in aqueous buffers commonly used in Protein A Chromatography
Dynamic binding capacity, Q B10	~35 mg hIgG/mL resin
Ligand	Alkali-stabilized Protein A-derived ( E. coli )
Ligand Coupling Method	Epoxy activation
Matrix	Highly cross-linked agarose, spherical
Particle size, d 50V	~85 µm
Storage	2 to 8°C, 20% Ethanol (alternative storage solution 2% benzyl alcohol)
pH stability, CIP	2–13.7
pH stability, operational	3–12

FAQs

Question: How much MabSelect SuRe resin is provided in this pack?

Answer:1 L.

Question: Is MabSelect SuRe used for capture or size-exclusion polishing?

Answer:It is a protein A affinity resin primarily used for monoclonal antibody capture.

Question: What is the supply medium for the resin?

Answer:A suspension in 20% ethanol.

Application Note

Cytiva MabSelect SuRe™ protein A affinity resin enables antibody capture in packed-bed purification workflows. The medium combines an engineered, alkali-tolerant protein A ligand with a rigid, highly cross-linked agarose support to bind IgG Fc regions while maintaining useful pressure-flow performance. Its tolerance of specified 0.1–0.5 M NaOH cleaning cycles supports resin reuse and chromatographic process development. The 1 L format is suited to column packing, process characterization and smaller-scale bioprocess campaigns using the same ligand chemistry as larger manufacturing packs. MabSelect SuRe is delivered as a suspension in 20% ethanol and should not be confused with MabSelect SuRe LX, which is a separate resin grade.

Ordering

Notice

Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
All quotations are subject to final confirmation, including product availability, lead time, batch information, shipping cost, and applicable export or handling requirements.
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