Cytiva, 17544405, Capto™ adhere multimodal chromatography resin, 10 L

Name: Capto™ adhere multimodal chromatography resin, 10 L
Brand: Cytiva
SKU: 17544405

Designed for post-protein A purification of monoclonal antibodies at process scale.

Catalog Number: 17544405

Pricing

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Category

Monoclonal Antibodies

Pack Size10 L

TagsChromatography resins Chromatography products Multimodal resins resin

CollectionsCytiva Chromatography Columns, Resins & Lab Glassware Cytiva Protein Analysis Equipment & Supplies Collection

Description

Capto™ adhere is a strong anioin exchange (AIEX) multimodal chromatography resin designed for purification of monoclonal antibodies (mAbs) after the protein A step at process scale.
It can be used in flow-through or bind/elute mode.
Wide operational window of pH and conductivity.
Resin fulfills industrial demands for security of supply, robust performance, and regulatory support.
Saves time and operating costs when used as part of a two-step chromatographic process with protein A capture.
Removes contaminants to formulation levels.
High capacity and productivity in flow-through mode.
Different selectivity from traditional IEX resins
Capto™ adhere resin is composed of a rigid, high-flow agarose matrix and a novel multimodal ligand. The strong multimodal ligand gives a different selectivity from that of conventional ion exchange (IEX) resins.
Second step in mAb chromatographic process
Capto™ adhere resin can remove key contaminants such as DNA, host cell proteins (HCP), leached protein A, dimers and larger aggregates, and viruses in a single step. Together with a protein A capture step , (using, for example, MabSelect™ SuRe resin ), Capto™ adhere resin allows the design of a two-step chromatographic process for mAbs.
Part of the Capto™ adhere family
For optimal performance of Capto™ adhere, screening and optimization of loading conditions is recommended, preferably using modern high-throughput process development tools, such as PreDictor™ 96-well filter plates.
Prepacked columns and other formats
Capto™ adhere resin is available in the following formats:
Process development scale
PreDictor™ Capto™ adhere filter plates , 96-well plates for high-throughput screening or process development.
PreDictor™ Capto™ adhere RoboColumn units , miniaturized columns for high-throughput process development.
HiScreen™ Capto™ adhere columns , optimized for method and process development.
f (x) column , prepacked and precharacterized chromatography column for fast and accurate mechanistic modeling.
Validation columns , scale-down columns for robust and reproducible process validation and process development (Tricorn™ format)
Lab scale (for manual or automated systems)
HiTrap™ Capto™ adhere columns , for easy use with a syringe, peristaltic pump, or chromatography system.
Process-scale
ReadyToProcess™ Capto™ adhere columns , 1 L and larger columns for clinical manufacturing that minimize the need for cleaning and cleaning validation.
Process characterization kits
Process characterization kits for Capto™ adhere and other resins are designed for studying the potential impact that resin ligand density might have on the process outcome.

Specifications

General

BioProcess resin	Yes
Certificate of Analysis	Yes
Chemical stability	Commonly used aqueous buffers, 1 M acetic acid, 1 M sodium hydroxide
Estimated shelf life from manufacture date	5 years
Ion Exchanger Type	Multimodal strong anion exchanger
Ionic Capacity	0.09-0.12 mmol Cl - /ml medium
Ligand	N-benzyl-n-methyl ethanolamine
Matrix	Highly cross-linked agarose
Particle size, d 50V	~75 µm
Pressure/Flow Specification	300 kPa at 600 cm/h, 1 m diameter column, 20 cm bed height
Storage	4 to 30°C, 20% Ethanol
pH stability, CIP	2–14
pH stability, operational	3–12

FAQs

Question: What is the package volume of this Capto adhere resin?

Answer:10 L.

Question: How does Capto adhere differ from a conventional anion exchanger?

Answer:Its multimodal ligand provides ionic and additional nonionic binding interactions.

Question: Which polishing mode is often used with Capto adhere?

Answer:Flow-through operation, with impurities retained while the product passes through.

Application Note

Cytiva Capto™ adhere is a multimodal chromatography resin used in downstream polishing of monoclonal antibodies and other biopharmaceutical products. Its N-benzyl-N-methyl ethanolamine ligand combines ionic, hydrogen-bonding and hydrophobic interactions on a highly cross-linked agarose matrix, allowing process developers to target aggregates, host-cell proteins, DNA and residual protein A under selected buffer conditions. The medium is often evaluated in flow-through polishing modes, where desired product passes through while selected impurities bind. This 10 L bulk pack supports process-scale column packing and larger purification campaigns. Capto adhere has different selectivity from conventional single-mode anion exchange resins and from Capto adhere ImpRes.

Ordering

Notice

Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
All quotations are subject to final confirmation, including product availability, lead time, batch information, shipping cost, and applicable export or handling requirements.
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