Description
About PreDictor™ plates for high-throughput process development PreDictor™ plates are disposable, 96-well filter plates for parallel screening of resins and chromatographic conditions. Data generated using PreDictor™ plates show good correlation with data from chromatography columns, making the plates an excellent tool for initial screening. The plates can be used with a robotic system or operated manually with a multichannel pipet (using vacuum or centrifugation) . Learn how our PreDictor™ plates can be used for developing HIC steps: Step-by-step HTPD workflow to optimize a HIC step Developing a HIC polishing step for removal of mAb aggregates Be sure to download Assist software to support the PreDictor™ plate workflow, from setup of experimental design to data evaluation. Learn more about HTPD . About Capto™ Phenyl (high sub) – a high-flow and high-capacity HIC resin Capto™ Phenyl (high sub) hydrophobic interaction chromatography (HIC) resin has a phenyl ligand for the capture and intermediate purification of mAbs, mAb variants, and other biomolecules. It combines high capacity, narrow specification range, high flow rate, and low backpressure to meet the demands of large-scale biopharmaceutical manufacturing today. Not sure which HIC resin you should use? We recommend starting with one of the kits below: PreDictor™ Capto™ HIC screening kit , a set of 96-well plates prefilled with six Capto™ hydrophobic interaction chromatography resins for use in high-throughput process development (HTPD). HiTrap™ Capto™ HIC selection kit , a set of five Capto™ HIC resins in HiTrap™ columns for resin selection and condition screening. Capto™ Phenyl (high sub) is available in multiple formats (Fig 1): Bulk resin bottles and containers of Capto™ Phenyl (high sub) resin for column packing. PreDictor™ Capto™ Phenyl (high sub) RoboColumn™ units , miniaturized columns for HTPD. HiTrap™ Capto™ Phenyl (high sub) 1 mL and 5 mL columns for easy use with a syringe, peristaltic pump, or chromatography system. HiScreen™ Capto™ Phenyl (high sub) columns optimized for method and process development. ReadyToProcess™ Capto™ Phenyl (high sub) columns , in various sizes for scale-up and GMP manufacturing. Process Characterization Kit Capto™ Phenyl (high sub) , designed for studying the potential impact that resin ligand density might have on the process outcome. Fig 1. Prepacked formats from Cytiva, to support various scales, from screening to GMP manufacturing.
