Cytiva, 17549804, MabSelect PrismA, 5 L

MabSelect PrismA™ affinity chromatography resin has been improved with an optimized high-flow agarose base matrix and a genetically engineered protein A-derived ligand. This allows future demands in mAb purification to be met, including processing of many bispecific antibodies.
Enhanced dynamic binding capacity allows high mass throughput of processed mAb per resin volume unit.
Excellent alkaline stability enables efficient cleaning and sanitization using 0.5–1.0 M NaOH for improved process economy, bioburden control, and robustness.
Covered by a comprehensive security of supply program, including dual sources of the agarose base matrix and protein A ligand.
The PrismA protein A ligand is also available in HiTrap Fibro™ and HiScreen Fibro™ PrismA chromatography units for ultrafast purification of mAbs.
Easily measure protein A leakage using the PrismA ELISA kit specifically designed for use with MabSelect PrismA™ resins.
The enhanced alkaline stability of MabSelect PrismA™ also provides opportunities for more robust mAb purification using periodic counter-current chromatography. The possibility for cleaning using 1 M NaOH increases bioburden control for continuous processes, which can be exposed to days or weeks of feed harvest.
For samples, contact your local sales representative or customer support.
MabSelect PrismA™ protein A resin builds on the proven track record of MabSelect™ and MabSelect SuRe™ resins in downstream processing of monoclonal antibodies.
Learn about ReadyToProcess MabSelect PrismA™ , prepacked HiScreen MabSelect PrismA™ , HiTrap MabSelect PrismA™ , PreDictor MabSelect PrismA™ or PreDictor Robocolumns MabSelect PrismA™ .
Learn how Bispecific antibodies (BsAb) can be purified using protein A chromatography in only a single step.
Learn about large scale column packing using MabSelect PrismA™ .
Learn about reducing bioburden and sanitization of MabSelect PrismA™