Cytiva, 17549816, HiScreen Fibro PrismA

The HiTrap Fibro™ and HiScreen Fibro™ PrismA adsorbents have a protein A cellulose fiber matrix with an open pore structure where mass transfer is governed by convective flow. This structure allows high mAb binding capacities at very short residence times by using rapid cycling chromatography. This results in cycle times of minutes instead of the hours needed for resin-based chromatography. Dynamic binding capacity is ~ 30 mg IgG/mL matrix. The Fibro technology platform is designed to scale up to manufacturing scale. The units will range from research scale with a capacity of approximately 12 mg per purification cycle (0.4 mL units) to GMP compatible units that can process up to 2000 L bioreactor harvest or 10 kg mAb in one working day by cycling multiple times. Applications Intensify protein A chromatography . Overcome chromatography challenges . Increase throughput with this automated two-step process . Cut lead times dramatically using high-throughput process development . Customer Case study: High throughput mAb purification . 14 questions of Fibro chromatography. Getting started Using resin-based columns? Fibro PrismA units connect to ÄKTA™ systems in the same way. And you can use the same buffers. Free E-learning: Getting started with Fibro