Description
Biacore Sensor Chip CM5 Matrix The CM5 sensor chip carries a matrix of carboxymethylated dextran covalently attached to a gold surface. Molecules can be covalently coupled to the sensor surface by exploiting available amine, thiol, aldehyde, or carboxyl functional groups on the ligand. The CM5 dextran matrix extends about 100 nm from the gold surface, and is flexible, allowing relatively free movement of attached ligands. An exceptionally versatile chip for SPR interaction analysis Sensor Chip CM5 is the most versatile and widely used dextran-based chip, suitable for most general-purpose surface plasmon resonance (SPR) applications. Carboxymethyl surface chemistry supports the study of many different types of ligands and binding partners–from small organic molecules, such as drug candidates, through to large molecular assemblies and even whole viruses. High binding capacity gives a high response, advantageous for capture assays and for interactions involving small molecules. High surface stability provides accuracy and precision, and allows repeated analysis on the same surface. Application examples include: FBDD-based screening for novel drugs against Hepatitis C virus (HCV) Surface plasmon resonance-based determination of adenovirus concentration on Biacore T200 Sensor chip formats for Biacore systems Biacore sensor chips are available in two formats: S series sensor chips are for use with Biacore 1 series, Biacore 8 series, Biacore T200, Biacore S200 and Biacore 4000 SPR systems. Sensor chips not designated with S series are designed for Biacore X100, and Biacore C SPR systems.
