Illumina, 20015273, Infinium® Assay: An Introduction – Customer Site

Name: Infinium® Assay: An Introduction – Customer Site
Brand: Illumina
SKU: 20015273

Three-day, hands-on instruction at customer site to familiarize users with the essential steps in the Infinium protocol. Course provides hands-on training in sample and BeadChip preparation, sample scanning using the iScan System, and primary data evaluation and analysis using array analysis software.

Catalog Number: 20015273

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Category

General Purpose Incubators

TagsMicroarray Kits Clinical research products

Description

Overview
The Infinium Global Diversity Array with Cytogenetics-8 is a scalable, cost-effective microarray that contains approximately 1.8M probes, with 160K probes supplementing the current Global Diversity Array manifest across more than 4800 tiered genes. Supplemental probes were selected based on the input from a cytogenetics research consortium and strategically localized near exons, in spatial consideration of existing probe placement, to deliver optimal performance in copy number variation analysis.
Detect structural variation in the human genome, including duplications, deletions, amplifications, copy-neutral loss of heterozygosity, and mosaicism.
Examine cytogenomic changes in constitutional diseases, cancers, and more.
Process sample types including saliva, blood, and buccal swabs using the PCR-free Infinium HD Assay with only 200 ng DNA per sample.
Analyze formalin-fixed paraffin-embedded (FFPE) paired tumor-normal samples when used with the appropriate FFPE cluster file.

Broad clinical research applications
Markers were selected from clinical research databases, including ClinVar, CPIC, and PharmGKB, for a variety of research applications, including risk profiling, pharmacogenomics, wellness characterization, and disease discovery.

Example workflow
Infinium Global Diversity Array with Cytogenetics-8
iScan System
Infinium Automation Option Packages
DRAGEN Array
Emedgene software

Related applications and methods
Chromosomal microarray analysis
Chromosomal microarrays reliably detect copy number and allelic contribution imbalances associated with constitutional disorders.
Cytogenomics
Together, next-generation sequencing and arrays enable cytogenomic analysis of chromosome aberrations for constitutional and cancer research.
Copy number variation analysis
Perform high-resolution copy number variation (CNV) analysis with Illumina array and next-generation sequencing solutions.

Specifications

General

Assay time	3 days
Automation capability	Automated array loader, Liquid handling robot(s)
Cancer type	Hematologic, Solid tumor
Description	The 8-sample Infinium Global Diversity Array with Cytogenetics-8 provides extensive targeted coverage of more than 4800 key genes across the genome. Approximately 1.8M markers are included on the BeadChip for high exonic coverage in regions of disease relevance, providing highly accurate copy number variation calls, and an average resolution of 1.5Mb.
Hands-on time	1 hour and 5 minutes for automated 8-beadchip workflow
Input quantity	200 ng
Instruments	iScan System
Method	Cytogenomic array , Genome-wide genotyping array
Nucleic acid type	DNA
Number of samples	8 samples per array
Specialized sample types	Blood, FFPE tissue, Buccal swabs, Saliva
Species category	Human
Technology	Microarray
Variant class	Single nucleotide polymorphisms (SNPs), Loss of heterozygosity (LOH), Chromosomal abnormalities, Copy number variants (CNVs)

Ordering

Notice

Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
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