Overview
The Infinium Global Screening Array-24 BeadChip is an advanced, scalable, and cost-effective solution for population-scale genetic studies.
Key features
Multiethnic genome-wide content selected for high imputation accuracy of > 1% across all 26 1000 Genomes Project Populations
High-throughput processing of hundreds to thousands of samples per week with a 3-day workflow for population-scale studies
Clinical research applications include disease risk profiling studies, pharmacogenomics research, wellness characterization, and complex disease discovery
Clinical research content in v3.0 includes variants with established disease associations, relevant pharmacogenomics markers, and curated exonic content derived from ClinVar, NHGRI, PharmGKB, and ExAC databases.
Over 15 million samples of the Global Screening Array have been ordered by researchers, healthcare networks, consumer genomics companies, and genomic service providers.
Precision medicine research initiatives around the world use the Global Screening Array to study disease risk, stratify samples, and incentivize participation across a large variety of clinical applications.
Applications
The Infinium Global Screening Array-24 is a powerful and cost-effective BeadChip for population-scale genetic studies, variant screening, and precision medicine research. It covers an extensive range of diseases, enabling validation of disease associations, risk profiling, preemptive screening research, and pharmacogenomics studies.
Example workflow
Infinium Global Screening Array-24 Kit
DesignStudio Custom Assay Design Tool
iScan System
Infinium Automation Packages
Clarity LIMS
GenomeStudio Software
Beeline Software
Related applications and methods
High-throughput genotyping
Large-scale genotyping with microarrays can identify variants associated with disease risk in large cohorts or populations.
Genome-wide association studies
Genome-wide association studies enable the discovery and characterization of genetic variants associated with disease.
SNP and SNV genotyping
Explore genotyping techniques and solutions to find single nucleotide polymorphisms and variants (SNPs and SNVs) using microarrays and sequencing.
Scalable High-Throughput Array Enables Ethnic Chinese Genome Database Development
Bringing Meaning to Genetic Information
Polygenic Risk Scores Could Become a Useful Tool in the Physician's Toolbox
Infinium Global Screening Array content
Inner pie shows the proportion of the array selected for genome-wide coverage, clinical research, and quality control (QC). Outer ring shows the weighted reference global allele frequency for unique variants present in 1kGP.1 Variants not in 1kGP are labeled. Counts represent unique variants.
Clinical research content on the Global Screening Array
Content was expertly selected from scientifically recognized databases to create a highly informative array for clinical research applications. Variant counts may be subject to change.
Broad spectrum of pharmacogenomics content on the Global Screening Array
Selected based on CPIC guidelines and PharmGKB database.2 PGx public database variants, variants annotated in PharmGKB, PharmVar, CPIC; Genome-wide PGx coverage, includes markers located in an extended ADME genes or CPIC level A genes including targeted imputation tag SNPs and CPIC level A CNV tags.
Extensive range of disease categories covered on the Global Screening Array
Global Diversity Array clinical research content features markers across a broad range of disease categories based on the NHGRI database.
(A) Variants sorted by range of pathology classifications according to ClinVar American College of Medical Genetics (ACMG) annotations.
(B) Global Diversity Array clinical research content by category within the ClinVar database. Variant counts may be subject to change.
Infinium microarrays provide outstanding versatility
Learn about population-scale applications enabled by the cost-effective high-throughput Infinium microarrays.
Infinium Global Screening Array-24 v3.0 Kit (48 Samples)
20030770
The Infinium Global Screening Array-24 v3.0 combines highly optimized, universal genome-wide backbone, expertly selected clinical research variants, and sample tracking content to create a highly economical array for population-scale genomics and screening. Each Kit contains 2 BeadChips, along with reagents for amplifying, fragmenting, hybridizing, labeling and detecting 48 DNA samples. View less
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Infinium Global Screening Array-24 v3.0 Kit (288 Samples)
20030771
The Infinium Global Screening Array-24 v3.0 combines highly optimized, universal genome-wide backbone, expertly selected clinical research variants, and sample tracking content to create a highly economical array for population-scale genomics and screening. Each Kit contains 12 BeadChips, along with reagents for amplifying, fragmenting, hybridizing, labeling and detecting 288 DNA samples. View less
Infinium Global Screening Array-24 v3.0 Kit (1152 Samples)
20030772
The Infinium Global Screening Array-24 v3.0 combines highly optimized, universal genome-wide backbone, expertly selected clinical research variants, and sample tracking content to create a highly economical array for population-scale genomics and screening. Each Kit contains 48 BeadChips, along with reagents for amplifying, fragmenting, hybridizing, labeling and detecting 1152 DNA samples. View less
Infinium Global Screening Array-24+ v3.0 Kit (48 Samples)
20030773
The Infinium Global Screening Array-24 v3.0 combines expertly selected and relevant clinical research variants with a robust genome-wide backbone covering global populations to create a highly economical array for population-scale genomics and screening. Each Kit contains 2 customizable BeadChips, along with reagents for amplifying, fragmenting, hybridizing, labeling and detecting 48 DNA samples View less
Infinium Global Screening Array-24+ v3.0 Kit (288 Samples)
20030774
Infinium Global Screening Array-24+ v3.0 Kit (288 Samples) View less
Infinium Global Screening Array-24+ v3.0 Kit (1152 Samples)
20030775
The Infinium Global Screening Array-24 v3.0 combines expertly selected and relevant clinical research variants with a robust genome-wide backbone covering global populations to create a highly economical array for population-scale genomics and screening. Each Kit contains 48 customizable BeadChips, along with reagents for amplifying, fragmenting, hybridizing, labeling and detecting 1152 DNA samples. View less
Infinium HTSE GSA-24+ v3.0(4,608 Spl)
20034098
Infinium HTSE GSA-24+ v3.0(4,608 Spl) View less
Infinium HTSE GSA-24+ v3.0(23,040 Spl)
20034099
Infinium HTSE GSA-24+ v3.0(23,040 Spl) View less
Infinium® Assay: An Introduction – Customer Site
20015273
Three-day, hands-on instruction at customer site to familiarize users with the essential steps in the Infinium protocol. Course provides hands-on training in sample and BeadChip preparation, sample scanning using the iScan System, and primary data evaluation and analysis using array analysis software. View less
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What is the Global Screening Array?
The Global Screening Array is a next-generation genotyping array that combines optimized, multiethnic genome-wide content and clinical research variants for population-scale genetics and screening investigations.
Version 3 of the Infinium Global Screening Array-24 BeadChip is available for research use only. It leverages the most up to date and relevant clinical research screening markers derived from ClinVar, CPIC, and PharmGKB.
What is the Infinium assay, and does the Global Screening Array use this assay?
The Infinium assay is a high-throughput SNP analysis chemistry that allows identification of SNPs for genotyping and methylation studies. The Global Screening Array uses the Infinium assay. Infinium assay-based microarray products have been adopted by a number of leading institutions for population-scale genotyping, epigenome-wide association studies, precision medicine research, and other applications.
Learn more about Illumina microarray technology or explore microarray kits .
Frequently purchased
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The 1000 Genomes Project. http://www.1000genomes.org . Accessed May 20, 2020.
PharmGKB, The Pharmacogenomics Knowledgebase. www.pharmgkb.org . Accessed May 20, 2020.
