Overview
The Infinium Global Diversity Array 8-Kit (GDA) BeadChip is a powerful, cost-effective array with optimized, multiethnic, genome-wide content.
Key features
Updated broad coverage of clinical research variants for a range of applications
Optimized content enables diversity in studies
High-throughput, scalable workflow allows users to gather and report data quickly
The GDA is the commercial version of the microarray trusted by this NIH precision medicine initiative, which will collect data from > 1M people to improve health outcomes.
A high-density SNP global backbone for cross-population imputation coverage of the genome enables polygenic risk score development and characterization of genetic architecture in diverse populations.
The robust genome-wide scaffold was designed to tag common and low-frequency variants in global populations through collaborations with the Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) and Population Architecture using Genomics and Epidemiology (PAGE). Content includes > 1K whole-genome sequences of African ancestry and populations throughout the Americas.
Applications
The Infinium Global Diversity Array-8 Kit is a powerful, cost-effective BeadChip with optimized, multiethnic genome-wide content for population-scale genetic studies, variant screening, and precision medicine research.
Example workflow
Infinium Global Diversity Array
DesignStudio Custom Assay Designer
iScan System
Infinium Automation Packages
Clarity LIMS
GenomeStudio Software
Beeline Software
Related applications and methods
High-throughput genotyping
Large-scale genotyping with microarrays can identify variants associated with disease risk in large cohorts or populations.
Genome-wide association studies
Genome-wide association studies (GWAS) enable the discovery and characterization of genetic variants associated with disease.
Pharmacogenomics
Pharmacogenomics studies how variations in the human genome affect our response to medications, helping to reduce adverse drug reactions and medical costs.
Infinium Global Diversity Array content
Inner pie shows the proportion of the array selected for genome-wide coverage, clinical research, and quality control (QC). Outer ring shows the weighted reference global allele frequency for unique variants present in 1kGP. 2 Variants not in 1kGP are labeled. Counts represent unique variants.
Clinical research content on the Global Diversity Array
Content was expertly selected from scientifically recognized databases to create a highly informative array for clinical research applications. Variant counts may be subject to change.
Broad spectrum of pharmacogenomics markers on the Global Diversity Array
Selected based on CPIC guidelines and PharmGKB database. 3 PGx public database variants, variants annotated in PharmGKB, PharmVar, CPIC; Genome-wide PGx coverage, includes markers located in an extended ADME genes or CPIC level A genes including targeted imputation tag SNPs and CPIC level A CNV tags.
Broad coverage of disease categories on the Global Diversity Array
(A) Variants sorted by range of pathology classifications according to ClinVar American College of Medical Genetics and Genomics (ACMG) annotations. (B) Global Diversity Array clinical research content by category within the ClinVar database. Variant counts may be subject to change.
QC markers on the Global Diversity Array
QC variants on the array enable various capabilities for sample tracking such as sex determination, continental ancestry, human identification, and more.
Resources
The Illumina Polygenic Risk Score solution is a comprehensive, easy-to-implement, and versatile genomic analysis tool set for translational researchers.
Infinium Global Diversity Array-8 v1.0 Kit (16 samples)
20031669
The Global Diversity Array (GDA) is a high-density, customizable genotyping tool built in collaboration with the All of Us U.S. Precision Medicine Initiative. The GDA delivers unparalleled data quality, powerful multi-ethnic coverage, and extensive coverage of clinically relevant variants and pharmacogenomics markers. Each kit contains two BeadChips, along with reagents for amplifying, fragmenting, hybridizing, labeling and detecting 16 DNA samples. View less
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Infinium Global Diversity Array-8 v1.0 Kit (48 Samples)
20031810
The Global Diversity Array (GDA) is a high-density, cutomizable genotyping tool built in collaboration with the All of Us U.S. Precision Medicine Initiative. The GDA delivers unparalleled data quality, powerful multi-ethnic coverage, and extensive coverage of clinically relevant variants and pharmacogenomics markers. Each kit contains six BeadChips, along with reagents for amplifying, fragmenting, hybridizing, labeling and detecting 48 DNA samples. View less
Infinium Global Diversity Array-8 v1.0 Kit (96 samples)
20031811
The Global Diversity Array (GDA) is a high-density, customizable genotyping tool built in collaboration with the All of Us U.S. Precision Medicine Initiative. The GDA delivers unparalleled data quality, powerful multi-ethnic coverage, and extensive coverage of clinically relevant variants and pharmacogenomics markers. Each kit contains twelve BeadChips, along with reagents for amplifying, fragmenting, hybridizing, labeling and detecting 96 DNA samples. View less
Infinium Global Diversity Array-8 v1.0 Kit (384 Samples)
20031812
The Global Diversity Array (GDA) is a high-density, customizable genotyping tool built in collaboration with the All of Us U.S. Precision Medicine Initiative. The GDA delivers unparalleled data quality, powerful multi-ethnic coverage, and extensive coverage of clinically relevant variants and pharmacogenomics markers. Each kit contains 48 BeadChips, along with reagents for amplifying, fragmenting, hybridizing, labeling and detecting 384 DNA samples. View less
Infinium Global Diversity Array-8+ v1.0 Kit (16 Samples)
20031813
Infinium Global Diversity Array-8+ v1.0 Kit (48 Samples)
20031814
The Global Diversity Array (GDA) is a high-density, customizable genotyping tool built in collaboration with the All of Us U.S. Precision Medicine Initiative. The GDA delivers unparalleled data quality, powerful multi-ethnic coverage, and extensive coverage of clinically relevant variants and pharmacogenomics markers. Each kit contains six BeadChips, along with reagents for amplifying, fragmenting, hybridizing, labeling and detecting 48 DNA samples. View less
Infinium Global Diversity Array-8+ v1.0 Kit (96 Samples)
20031815
Infinium Global Diversity Array-8+ v1.0 Kit (384 Samples)
20031816
Infinium® Assay: An Introduction – Customer Site
20015273
Three-day, hands-on instruction at customer site to familiarize users with the essential steps in the Infinium protocol. Course provides hands-on training in sample and BeadChip preparation, sample scanning using the iScan System, and primary data evaluation and analysis using array analysis software. View less
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How are the Global Diversity Array and the Global Diversity Array with Enhanced PGx different?
The Infinium GDA delivers the most cost-effective per variant coverage within the Illumina human array portfolio and is ideal for precision medicine programs aiming to maximize return on genotyping investments. The Infinium GDA with Enhanced PGx Content is the most comprehensive microarray available for PGx research versus all commercially available microarrays. 1 See more differences on the Infinium GDA with Enhanced PGx Content product page .
What is a polygenic risk score (PRS)?
A polygenic risk score (PRS) represents the total number of genetic variants an individual has that increase their risk of developing a certain complex condition or disease. The Global Diversity Array 8-Kit enables researchers to develop PRS assessment in diverse populations. Learn more about polygenic risk scores .
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Data calculations on file. Illumina, Inc. March 2021.
The 1000 Genomes Project. 1000 genomes.org. Accessed August 24, 2021.
PharmGKB, The Pharmacogenomics Knowledgebase. www.pharmgkb.org . Accessed August 4, 2021.
