Overview
The Infinium Mouse Methylation BeadChip Kit offers a unique combination of comprehensive, expert-selected coverage and high sample throughput.
Supports genome-wide DNA methylation studies
Enables epigenetic analysis of virtually all murine strains used in research laboratories
Interrogates 285K methylation sites per sample at single-nucleotide resolution
Provides a PCR-free protocol using the powerful Infinium HD Assay for epigenetic studies
Comprehensive coverage across gene regions
The Infinium Mouse Methylation BeadChip provides balanced coverage of CpG islands, translation start sites, enhancers, imprinted loci, and other regions. Infinium HD chemistry enables content selection independent of bias limitations often associated with methylated DNA capture methods.
High assay reproducibility
The Infinium Mouse Methylation BeadChip achieves > 98% reproducibility for technical replicates and shows high correlation with whole-genome bisulfite sequencing data.
Broad range of applications
Enables epigenome-wide association studies, xenograft experiments, preclinical research, and more.
Applications
The Infinium Mouse Methylation BeadChip powers a broad spectrum of murine epigenetic analysis studies, including epigenome-wide association studies, preclinical research, xenograft studies, and more.
Example workflow
Infinium Mouse Methylation BeadChip
Related applications and methods
DNA methylation analysis
Genome-wide methylation profiling studies with microarray and NGS technologies can provide novel insights into the functional impact of methylation.
Epigenetic analysis
Illumina offers solutions for epigenetic analysis. Use our tools to study epigenetic modifications and their impact on gene regulation.
Gene expression analysis
Learn how to profile gene expression changes for a deeper understanding of biology.
Broad coverage using Infinium I and Infinium II assay designs
The array uses both Infinium I and Infinium II assays. Infinium I assay design employs two bead types per CpG locus, 1 each for the methylated and unmethylated states. The Infinium II design uses 1 bead type, with the methylated state determined at the single base extension step after hybridization.
Integrated data analysis with Illumina GenomeStudio Software
GenomeStudio Software supports DNA methylation analysis on any platform. Data are displayed in intuitive graphics such as heatmaps.
10 Things to Know about the Infinium Mouse Methylation BeadChip
Dr. Wanding Zhou presents an overview of this powerful tool for mouse researchers.
Methylation array data analysis tips
Experts discuss their strategies for analyzing Illumina methylation array data.
Infinium Mouse Methylation BeadChip Kit (24 samples)
20041558
Includes two, 12-sample BeadChips and reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 24 DNA samples. Requires ≥ 250 ng DNA for input. Each kit is processed as a single batch. View less
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Infinium Mouse Methylation BeadChip Kit (48 samples)
20041559
Includes four, 12-sample BeadChips and reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 48 DNA samples. Requires ≥ 250 ng DNA for input. Each kit is processed as a single batch. View less
Infinium Mouse Methylation BeadChip Kit (96 samples)
20041560
Includes eight, 12-sample BeadChips and reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 96 DNA samples. Requires ≥ 250 ng DNA for input. Each kit is processed as a single batch. View less
Infinium Mouse Methylation275k-12+ v1.0 Kit (24 Samples)
20041561
Includes two, 12-sample BeadChips and reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 24 DNA samples. Customize content with an additional 3K–10K markers using DesignStudio or select from a list of add-on content available as consortia boosters. Requires ≥ 250 ng DNA for input. Each kit is processed as a single batch. View less
Infinium Mouse Methylation 275k-12+ v1.0 Kit (48 Samples)
20041562
Includes four, 12-sample BeadChips and reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 48 DNA samples. Customize content with an additional 3K–10K markers using DesignStudio or select from a list of add-on content available as consortia boosters. Requires ≥ 250 ng DNA for input. Each kit is processed as a single batch. View less
Infinium Mouse Methylation275k-12+ v1.0 Kit (96 Samples)
20041563
Includes eight, 12-sample BeadChips and reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 96 DNA samples. Customize content with an additional 3K–10K markers using DesignStudio or select from a list of add-on content available as consortia boosters. Requires ≥ 250 ng DNA for input. Each kit is processed as a single batch. View less
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How do I analyze the Infinium Mouse Methylation BeadChip data?
The GenomeStudio Methylation Module extracts beta values and provides clustering for Infinium Mouse Methylation BeadChip data. GenomeStudio controls normalization with the Mouse Methylation BeadChip is not supported at this time. Also, the BeadArray Controls Reporter software tool is not supported at this time.
There are many freeware applications in Bioconductor, such as SeSAMe, that provide enhanced normalization and visualization options. Illumina does not provide support for these freeware solutions directly.
Can the array distinguish 5-hydroxymethylcytosine from 5-methylcytosine?
Illumina has not validated the array for 5-hMc. However, publications have used the Infinium HumanMethylation450K and MethylationEPIC BeadChips for 5-hMc analysis and it is possible that this protocol will work on the Infinium Mouse Methylation BeadChip.
For more information, see Nazor KL, Boland MJ, Bibikova M, et al. Application of a low cost array-based technique—TAB-Array—for quantifying and mapping both 5mC and 5hmC at single base resolution in human pluripotent stem cells . Genomics. 2014;104(5):358-367. doi: 10.1016/j.ygeno.2014.08.014
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