Overview
DRAGEN (Dynamic Read Analysis for GENomics) Array secondary analysis is a powerful bioinformatics software for Infinium array-based assays. DRAGEN Array uses cutting-edge data analysis tools to provide accurate, comprehensive, and highly efficient secondary analysis to maximize genomic insights and meet your research needs.
Accurate and efficient analysis
High quality, rapid results for multiple applications including genotyping, CNV calling, pharmacogenomics (PGx) analysis, and methylation QC.
Comprehensive workflow
DRAGEN Array is part of the comprehensive Infinium microarray solution. Choose from custom, semi-custom or ready-to-use microarrays with expertly designed content; then process, scan and analyze data with a rapid DNA-to-data workflow.
Cloud and local deployment
DRAGEN Array offers a local, command-line package (no specialized field programmable gate array (FPGA) server or hardware required) and a cloud-based package with an intuitive graphical user interface (GUI).
Software updates
Genotyping, PGx copy number variant (CNV) calling, and star allele annotation for the following Infinium microarrays: Infinium Global Diversity Array with Enhanced PGx
Increased coverage of high-priority PGx genes: Star allele annotation now covers CYP2E1, CYP1A2, ABCG2, CYP2C8, HMGCR, UGT1A4, UGT2B15, F13A1, and HLA-B*15:02. CNV calling now covers SULT1A1.
Methylation quality control (QC): High-throughput and quantitative reporting of QC metrics for Infinium methylation arrays
Single nucleotide variant (SNV) genotyping analysis from any human Infinium microarray
Genome-Wide CNV and LOH detection with optional bedgraph files to power visualization
See the DRAGEN Array release notes for additional information and the full list of features.
Applications
DRAGEN Array provides accurate, comprehensive and efficient secondary analysis for Infinium microarrays.
Description: Variant types detected
Genotyping: Provides greater than 99.5% genotyping accuracy for any human Infinium genotyping array 1 .
PGx – CNV calling: Provides greater than 95% PGx CNV accuracy 2 . PGx CNV coverage on 6 target genes across 9 target regions.
PGx – star allele annotation: Provides PGx star allele and variant coverage across 1700+ targets for 50+ genes. Assess hard to discern PGx genes, including the elusive CYP2D6 with greater than 98% call rate 3 .
Cytogenetics: Genome-Wide CNV and LOH detection with optional bedgraph files to power visualization.
Methylation QC: Provides high-throughput, quantitative methylation quality control.
For more information visit: https://help.dragenarray.illumina.com/overview/our-features
Example workflow
Infinium microarrays
Infinium Automation Option Packages
iScan System
AutoLoader 2.x
DRAGEN Array
GenomeStudio Software
Clarity LIMS
Emedgene software
Related applications and methods
Cytogenomics
Understanding chromosome aberrations through cytogenetic analysis is an integral part of current genomic medicine, playing a role in research into both constitutional disorders and cancer.
Polygenic Risk Scores
Polygenic risk scores represent the total number of genetic variants an individual has that increase their risk of developing a particular disease.
Methylation Arrays
Methylation arrays enable high-throughput, quantitative interrogation of methylation sites across the genome at single-nucleotide resolution.
Figures
DRAGEN Array cloud analysis, step 1
Navigate to 'Runs – Microarray Analysis Setup' to get started with analysis.
DRAGEN Array cloud Analysis, step 2
Set up the analysis configuration.
DRAGEN Array cloud analysis, step 3
Select sample for analysis with Import Sample Sheet, Select BeadChips, or Import IDAT Files.
DRAGEN Array cloud analysis, step 4
View your results.
Efficient PGx analysis
Genotyping, PGx CNV calling, and star allele annotation in a single platform producing multiple output options.
Star allele annotation
Example of a star allele annotation JSON file to be used in downstream processing. Provides supporting variants, missing variants and alleles tested.
Methylation QC with adjustable thresholds
21 control metrics assess the quality of outputs. Adjustable pass/fail thresholds accommodate scanner differences, sample type differences, or study design preferences.
DRAGEN Array Local - star allele annotation
20109885
Per sample analysis quota for star allele calling using DRAGEN Array Local. One per sample analysis quota is needed per sample analyzed for star allele calling using the star-allele call subcommand. DRAGEN Array Local is a command-line software with no FPGA hardware or specialized server required and is downloadable from the Illumina Support Site. Internet is required for per sample quota check. View less
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DRAGEN Array Cloud - star allele annotation
20109886
Per sample analysis quota for star allele calling using DRAGEN Array Cloud. One per sample analysis quota is needed per sample analyzed for star allele calling using the analysis type, DRAGEN Array – PGx – star allele calling. DRAGEN Array Cloud provides analysis kickoff using BaseSpace Sequence Hub. The BaseSpace Sequence Hub access is facilitated by an Illumina Connected Analytics (Basic, Professional, or Enterprise) annual subscription. iCredits are used to store data on the cloud platform. View less
Illumina Analytics - 1 iCredit
20042038
iCredits are used for data storage and analysis on either BaseSpace Sequence Hub or Illumina Connected Analytics. View less
Illumina Analytics Starter Pack - 1,000 iCredits
20042039
Illumina Analytics - 5,000 iCredits
20042040
Illumina Analytics - 50,000 iCredits
20042041
Illumina Analytics - 100,000 iCredits
20042042
ICA Basic Annual Subscription
20044874
Illumina Connected Analytics (ICA) Basic Annual Subscription. This product includes 1 year of access to ICA Basic, including sequencing instrument connectivity, data management capabilities, and access to pre-packaged analysis tools. View less
ICA Professional Annual Subscription
20044876
Illumina Connected Analytics (ICA) Professional Annual Subscription. This product includes 1 year of access to ICA, including sequencing instrument connectivity, data management capabilities, access to pre- packaged tools, and the ability to create customized workflows composed of tools, pipelines, data warehouses, and notebooks. View less
ICA Enterprise Annual Subscription
20038994
Illumina Connected Analytics (ICA) Enterprise Annual Subscription. This product includes 1 year of access to ICA Enterprise, including sequencing instrument connectivity, data management capabilities, custom and pre-packaged analysis tools, and the Base module for data warehousing and mining. ICA Enterprise also includes optional HIPAA BAA (US-only), single sign-on (SSO), and a service level agreement (SLA). View less
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References
1,2,3 - Illumina data on file, 2023. Read more
