Description
Overview
This BeadChip offers excellent genome-wide variation analysis for population genetics and precision medicine research. It is designed for studying diverse populations, including underrepresented ethnic groups. It features:
Approximatley 1.2M markers that span the human genome
Ethnically diverse backbone
Coverage of genes necessary for molecular blood typing, clinical research, and population studies
Enhanced flexibility with capacity for up to 50K custom markers
Automated, scalable workflow provides a 2-2.5-day turnaround time
Formamide-free reagents support environmentally friendly protocol
Infinium EX format compatible with powerful Infinium liquid handling instruments with advanced software
What is needed to implement the Infinium EX genotyping workflow?
You will need the following products:
iScan System
Infinium EX array kit, such as the Global Screening Array-48 v4.0 kit
Infinium Automated Pipetting System with ILASS, to be used for post-amplification steps
Infinium Amplification System (Optional), to be used to automate pre-PCR steps (WGA)
Infinium EX/XT starter kit
What are the advantages of the Infinium EX platform?
Throughput:
The ability to run 48 samples per BeadChip on GSA v4 and scale up to 11,520 samples per week
iScan System with Infinium liquid handler instruments can scale up to hundreds of thousands of samples per year
Automation: Illumina Lab Automation Software Solution (ILASS) guides the user through the steps of the workflow via an intuitive user interface and provides on-deck validation, meaning the consumables loaded on the liquid handling robots are verified prior to use regardless of whether the customer is using LIMS. Real-time integration with cloud-based Clarity LIMS supports compliance with eSignature capability, audit trails, reagent and lot tracking, preset protocols, and privacy and security controls, which is critical for high-throughput customers.
How does the workflow for Infinium EX arrays differ from previous Infinium workflows?
Whole-genome amplification step is 3 hr for Infinium EX compared with 24 hr for legacy Infinium workflows, reducing total workflow time by 20%
Input DNA required for Infinium EX genotyping workflow is 100 ng compared with 200 ng for legacy workflows
Reagents are EH&S-friendly and formamide free
ILASS provides an improved UI and support experience
Updated automation and software allow integration with cloud-based analysis
How does the content differ between the Infinium Global Screening Array-48 v4.0 and Infinium Global Clinical Research Array-24 v1.0 content?
Both arrays feature a multiethnic genome-wide backbone with content for population studies, variant screening, and precision medicine research. In addition to this, Infinium Global Clinical Research Array-24 v1.0 covers additional clinical research markers from ACMG 73 and gnomAD exome to increase coverage of underrepresented populations.
Example workflow
Infinium Global Clinical Research Array-24
iScan System
Illumina Connected Analytics
Clarity LIMS software
DRAGEN Array
Related applications and methods
Pharmacogenomics (PGx)
Pharmacogenomics, the study of how variations in the human genome affect our response to medications, may help reduce adverse drug reactions and medical costs.
Population genomics
Population genomics programs integrate large-scale genomic and clinical research data into a learning health system, driving health care innovation.
Genomics in drug discovery and development
Reduce risks and improve development outcomes through improved insights
Clinical research content on the Global Screening Array
Content was expertly selected from scientifically recognized databases to create a highly informative array for clinical research applications. Variant counts may be subject to change.
Infinium Global Clinical Research Array-24 v1.0 Kit (24 samples)
20065215
Includes one, 24-sample BeadChip and reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 24 DNA samples. Requires 100 ng DNA for input. Each kit is processed as a single batch. View less
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Infinium Global Clinical Research Array-24 v1.0 Kit (96 samples)
20068337
Includes four, 24-sample BeadChips and reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 96 DNA samples. Requires 100 ng DNA for input. Each kit is processed as a single batch. View less
Infinium Global Clinical Research Array-24 v1.0 Kit (1152 samples)
20068338
Includes 48, 24-sample BeadChips and reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 1152 DNA samples. Requires 100 ng DNA for input. Each kit is processed as a single batch. View less
Infinium Global Clinical Research Array-24+ v1.0 Kit (24 spl)
20068351
Infinium Global Clinical Research Array-24+ v1.0 Kit (24 spl) View less
Infinium Global Clinical Research Array-24+ v1.0 Kit (96 spl)
20068352
Infinium Global Clinical Research Array-24+ v1.0 Kit (96 spl) View less
Infinium Global Clinical Research Array-24+ v1.0 Kit (1152 spl)
20068353
Infinium Global Clinical Research Array-24+ v1.0 Kit (1152 spl) View less
Illumina Hybridization Oven (110V)
SE-901-1001
Includes a rotating hybridization wheel with variable rotation speed of 5–60 rpm and a temperature range from 0°C to 100°C. Holds up to 24 BeadChips at one time. (110 V) View less
Illumina Hybridization Oven (220V)
SE-901-1002
Includes a rotating hybridization wheel with variable rotation speed of 5–60 rpm and a temperature range from 0°C to 100°C. Holds up to 24 BeadChips at one time. (220 V) View less
Infinium EX/XT Hybridization Chamber
20011755
Infinium EX/XT Hybridization Chamber supporting the hybridization of DNA samples to BeadChips. View less
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