Illumina, 20065216, Infinium Global Clinical Research Array with Enhanced PGx-24 v1.0 Kit (24 samples)

Name: Infinium Global Clinical Research Array with Enhanced PGx-24 v1.0 Kit (24 samples)
Brand: Illumina
SKU: 20065216

Includes one, 24-sample BeadChip and reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 24 DNA samples. Requires 200 ng DNA for input. Each kit is processed as a single batch.

Catalog Number: 20065216

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Category

Fluorescence Quantitation Kits

Pack Size1.0 Kit

TagsMicroarray Kits

Description

Infinium Global Clinical Research Array with Enhanced PGx-24 v1.0 Kit
This microarray offers comprehensive, genome-wide coverage of pharmacogenomic (PGx) markers and features a fast, highly scalable automated workflow.
Infinium Global Clinical Research Array with Enhanced PGx-24 v1.0 English Brazilian Portuguese French German Italian Spanish Data sheet PDF 1 MB 6 versions
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Overview
This microarray is designed for high-throughput pharmacogenomics (PGx) and large-scale genotyping studies. The 24-sample size offers an excellent mix of variant coverage and scalability while featuring:
Over 1.2M genome-wide markers, including critical PGx variants, replacing multiple arrays and PCR assays
35,000 variants from recognized PGx databases, including PharmGKB, CPIC, PharmVar, and ClinVar
100% coverage of priority level A and B CPIC genes
Targeted gene amplification step for analysis of hard-to-assess PGx genes like CYP2D6, CYP2B6, and TPMT
10,000 marker custom add-on capacity
Improved coverage of underrepresented populations compared with Infinium Global Screening Array-24 v3.0 and Infinium Global Screening Array-48 v4.0
Genome-wide coverage of variants with established disease associations, relevant PGx markers, and curated exonic content derived from ClinVar, NHGRI, PharmGKB, and ExAC databases.
Infinium EX format is compatible with the Infinium Amplification System and the Infinium Automated Pipetting System with ILASS to enable a scalable 2.5-day workflow.
DRAGEN Array secondary analysis enables accurate, comprehensive, and efficient CNV calling and star allele annotation.

Applications
Powerful array for genome-wide pharmacogenomics markers. This tool also supports clinical research and molecular blood typing studies with diverse and underrepresented groups.

Example workflow
Infinium Global Clinical Research Array with Enhanced PGx
DesignStudio
DesignStudio is a web-based assay design tool to help researchers design and order custom genotyping microarray probes or custom sequencing assays.
iScan System
The iScan microarray scanner supports high-throughput BeadChip processing, scanning hundreds to thousands of samples quickly and accurately.
Infinium Automated Pipetting System
Automation options with robot control software for Infinium assays streamline sample preparation workflows and reduce errors.
Infinium Amplification System
DRAGEN Array
DRAGEN Array provides accurate, comprehensive and efficient secondary analysis for Infinium microarrays.

Related applications and methods
Understand how variations in the human genome affect our response to medications
Pharmacogenomics, the study of how variations in the human genome affect our response to medications, may help reduce adverse drug reactions and medical costs.

Broad spectrum of pharmacogenomics markers
Clinical research content developed from an extensive list of pharmacogenomics markers selected based on CPIC guidelines and the PharmGKb database. 1,2 Content includes variants annotated in PharmGKb, genome-wide PGx coverage, extended AdMe genes, 3 CPIC level A genes, and targeted imputation tag SNPs.

Disease research content covering diverse populations
The Infinium Global Clinical Research Array with Enhanced PGx-24 v1.0 includes extensive coverage of phenotypes and disease classifications based on nhGRI GwAs database categories.

Distribution of variant pathology classifications according to Clinvar and ACMG annotations
Variants cover a range of pathogenic and nonpathogenic evidence.

Clinical research content
Expertly selected clinical research content from key databases supports a broad range of applications.

QC content by category
The Infinium Global Clinical Research Array with enhanced PGx-24 v1.0 contains ~9K markers enabling various sample tracking functions such as sex determination, continental ancestry, human linkage, and more.
Counts contain some markers that are represented in multiple QC categories.
References
Whirl-Carrillo M, Huddart R, Gong L, et al. An Evidence-Based Framework for Evaluating Pharmacogenomics Knowledge for Personalized Medicine . Clin Pharmacol Ther. 2021;110(3):563572. doi:10.1002/cpt.2350
Clinical Pharmacogenetics Implementation Consortium (CPIC). cpicpgx.org . Accessed September 13, 2024.
Gaedigk A, Casey ST, Whirl-Carrillo M, Miller NA, Klein TE. Pharmacogene Variation Consortium: A Global Resource and Repository for Pharmacogene Variation . Clin Pharmacol Ther. 2021;110(3):542-545. doi:10.1002/cpt.2321.
Infinium Global Clinical Research Array with Enhanced PGx-24 v1.0 Kit (24 samples)
20065216
Includes one, 24-sample BeadChip and reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 24 DNA samples. Requires 200 ng DNA for input. Each kit is processed as a single batch. View less
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Infinium Global Clinical Research Array with Enhanced PGx-24 v1.0 Kit (96 samples)
20068339
Includes four, 24-sample BeadChips and reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 96 DNA samples. Requires 200 ng DNA for input. Each kit is processed as a single batch. View less
Infinium Global Clinical Research Array with Enhanced PGx-24 v1.0 Kit (1152 samples)
20068340
Includes 48, 24-sample BeadChips and reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 1152 DNA samples. Requires 200 ng DNA for input. Each kit is processed as a single batch. View less
Infinium Global Clinical Research Array with Enhanced PGx-24+ v1.0 Kit (24 samples)
20068354
Infinium Global Clinical Research Array with Enhanced PGx-24+ v1.0 Kit (24 samples) View less
Infinium Global Clinical Research Array with Enhanced PGx-24+ v1.0 Kit (96 samples)
20068355
Infinium Global Clinical Research Array with Enhanced PGx-24+ v1.0 Kit (96 samples) View less
Infinium Global Clinical Research Array with Enhanced PGx-24+ v1.0 Kit (1152 samples)
20068356
Infinium Global Clinical Research Array with Enhanced PGx-24+ v1.0 Kit (1152 samples) View less
DRAGEN Array Local - star allele annotation
20109885
Per sample analysis quota for star allele calling using DRAGEN Array Local. One per sample analysis quota is needed per sample analyzed for star allele calling using the star-allele call subcommand. DRAGEN Array Local is a command-line software with no FPGA hardware or specialized server required and is downloadable from the Illumina Support Site. Internet is required for per sample quota check. View less
DRAGEN Array Cloud - star allele annotation
20109886
Per sample analysis quota for star allele calling using DRAGEN Array Cloud. One per sample analysis quota is needed per sample analyzed for star allele calling using the analysis type, DRAGEN Array – PGx – star allele calling. DRAGEN Array Cloud provides analysis kickoff using BaseSpace Sequence Hub. The BaseSpace Sequence Hub access is facilitated by an Illumina Connected Analytics (Basic, Professional, or Enterprise) annual subscription. iCredits are used to store data on the cloud platform. View less
Illumina Analytics - 1 iCredit
20042038
iCredits are used for data storage and analysis on either BaseSpace Sequence Hub or Illumina Connected Analytics. View less
Illumina Analytics Starter Pack - 1,000 iCredits
20042039
Illumina Analytics - 5,000 iCredits
20042040
Illumina Analytics - 50,000 iCredits
20042041
Illumina Analytics - 100,000 iCredits
20042042
ICA Basic Annual Subscription
20044874
Illumina Connected Analytics (ICA) Basic Annual Subscription. This product includes 1 year of access to ICA Basic, including sequencing instrument connectivity, data management capabilities, and access to pre-packaged analysis tools. View less
ICA Professional Annual Subscription
20044876
Illumina Connected Analytics (ICA) Professional Annual Subscription. This product includes 1 year of access to ICA, including sequencing instrument connectivity, data management capabilities, access to pre- packaged tools, and the ability to create customized workflows composed of tools, pipelines, data warehouses, and notebooks. View less
ICA Enterprise Annual Subscription
20038994
Illumina Connected Analytics (ICA) Enterprise Annual Subscription. This product includes 1 year of access to ICA Enterprise, including sequencing instrument connectivity, data management capabilities, custom and pre-packaged analysis tools, and the Base module for data warehousing and mining. ICA Enterprise also includes optional HIPAA BAA (US-only), single sign-on (SSO), and a service level agreement (SLA). View less
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How does the workflow for GCRA with ePGx differ from previous Infinium workflows?
The whole-genome amplification step is 3 hrs for Infinium EX compared with 24 hrs for legacy workflows
There is an additional step for targeted gene amplification (TGA) to disambiguate pseudogenes
Kits include updated EH&S-friendly reagents that are formamide-free
ILASS provides an improved UI (user interface) and support experience

What liquid handler automation can be used to run the assay?
Infinium Automated Pipetting System with ILASS (IAPS with ILASS): Required for post-amplification steps
Infinium Amplification System (IAS): Optional for pre-PCR steps (whole genome amplification and targeted gene amplification). These automation instruments offer:
High throughput capabilities: the IAS can process 4 plates in 25 minutes and the IAPS with ILASS can process 1 plate in 25 minutes
Efficiency: Use 8-tip and 96-tip heads (disposable tips are provided by the customer)
Automation software: ILASS, which comes with out-of-the-box integration with hosted Clarity LIMS software

How does this product compare to the Infinium Global Screening Array with Enhanced PGx-48 v4.0?
The Infinium Global Clinical Research Array with Enhanced PGx-24 provides the optimal balance of PGx and genome-wide content, throughput, and coverage of diverse populations. The additional content in this array compared with the Infinium Global Screening Array with Enhanced PGx-48 v4.0 are variants associated with disease risk and clinical research. This array has better imputation coverage across even minor allele frequencies compared with screening array solutions from other vendors.
The additional content on this array compared with the Infinium Global Clinical Research Array is the Enhanced PGx content, which includes 100% coverage of priority level A and B CPIC genes and variants from recognized PGx databases such as PharmGKB, PharmVar, CPIC, and ClinVar.
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Specifications

General

Sample throughput	5,760 samples/week max throughput per iScan System. Throughput and scan times will vary based on system configuration.
Number of samples	24 samples per array
Number of markers	1,185,155 markers with 10,000 custom marker capacity
Assay type	Infinium EX
Automation capability	Liquid handling robot(s)
Input quantity	200 ng
Instruments	iScan System
Method	High-throughput genotyping array , Genome-wide genotyping array
Nucleic acid type	DNA
Specialized sample types	Blood
Species category	Human
Technology	Microarray
Variant class	Single nucleotide polymorphisms (SNPs), Structural variants, Single nucleotide variants (SNVs), Insertions-deletions (indels), Copy number variants (CNVs)

Ordering

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Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
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