Illumina, 20066470, Infinium Global Screening Array with Cytogenetics (288 Samples)

Name: Infinium Global Screening Array with Cytogenetics (288 Samples)
Brand: Illumina
SKU: 20066470

The Infinium Global Screening Array with Cytogenetics-24, 288 Samples Kit combines a versatile genome-wide backbone with optimized content for advanced cytogenetic analysis. Each BeadChip assays ~700K total variants. The kit contains 12 BeadChips and the necessary reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 288 samples.

Catalog Number: 20066470

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Total RNA Isolation Kits

TagsClinical research products

Description

Infinium Global Screening Array with Cytogenetics-24 | Genotyping array
Detect structural variation in the human genome and examine cytogenomic changes in constitutional diseases and cancers with this research microarray.
Infinium™ Global Screening Array with Cytogenetics-24 v1.0 BeadChip Data sheet PDF < 1 MB
Data sheet PDF < 1 MB
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Overview
The Infinium Global Screening Array-24 with Cytogenetics-24 contains approximately 700K variants, including 80K supplemental probes targeting more than 4800 tiered genes and regions with known disease associations. Target variants were selected based on the input from a cytogenetics research consortium and include genes defined by ClinGen as pathogenic and likely pathogenic along with an enhanced backbone for a modern, up-to-date assay.
Detect structural variation in the human genome, including duplications, deletions, amplifications, copy-neutral loss of heterozygosity, and mosaicism
Examine cytogenomic changes in constitutional diseases, cancers, and more
Process sample types including saliva, blood, and buccal swabs using the polymerase chain reaction (PCR)-free Infinium HTS Assay with only 200 ng DNA per sample
Analyze formalin-fixed paraffin-embedded (FFPE) paired tumor-normal samples when used with the appropriate FFPE cluster file

Broad clinical research applications
Markers were selected from clinical research databases, including ClinVar, CPIC, and PharmGKB for research applications, including risk profiling, pharmacogenomics, wellness characterization, and disease discovery.

Example workflow
Infinium Global Screening Array with Cytogenetics-24
iScan System
Infinium Automation Packages
DRAGEN Array
Emedgene software

Related applications and methods
Chromosomal microarray analysis
Chromosomal microarrays reliably detect copy number and allelic contribution imbalances associated with constitutional disorders.
Cytogenomics
Together, next-generation sequencing and arrays enable cytogenomic analysis of chromosome aberrations for constitutional and cancer research.
Copy number variation analysis
Perform high-resolution copy number variation (CNV) analysis with Illumina array and next-generation sequencing solutions.

Specifications

General

Assay time	3 days
Automation capability	Automated array loader, Liquid handling robot(s)
Cancer type	Hematologic, Solid tumor
Description	The 24-sample Infinium Global Screening Array with Cytogenetics-24 provides targeted coverage of more than 4800 key genes across the genome. Approximately 700K markers are included on the BeadChip for high exonic coverage in regions of disease relevance, providing highly accurate copy number variation calls, and an average resolution of 2.5Mb.
Hands-on time	1 hour and 5 minutes for automated 8-beadchip workflow
Input quantity	200 ng
Instruments	iScan System
Method	Cytogenomic array , High-throughput genotyping array
Nucleic acid type	DNA
Number of samples	24 samples per array
Specialized sample types	Blood, FFPE tissue, Buccal swabs, Saliva
Species category	Human
Technology	Microarray
Variant class	Single nucleotide polymorphisms (SNPs), Loss of heterozygosity (LOH), Chromosomal abnormalities, Copy number variants (CNVs)

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