Illumina, 20068361, Infinium Global Screening Array-48+ v4.0 Kit (96 Samples)

Name: Infinium Global Screening Array-48+ v4.0 Kit (96 Samples)
Brand: Illumina
SKU: 20068361

The Global Screening Array-48 v4.0 Kit, built on proven Infinium technology, offers exceptional coverage of key genome-wide clinical content, and provides a cost-effective and highly scalable workflow to support population-scale clinical research studies

Catalog Number: 20068361

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Category

Fluorescence Quantitation Kits

Pack Size4.0 Kit

TagsMicroarray Kits

Description

Infinium Global Screening Array-48 Kit
The Global Screening Array-48 v4.0 Kit is a scalable, cost-effective solution designed to support high-volume genotyping studies.
Infinium Global Screening Array-48 v4.0 English Brazilian Portuguese French German Italian Japanese Korean Spanish Data sheet PDF < 1 MB 8 versions
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Overview
The Infinium Global Screening Array-48 v4.0 is our most advanced scalable and cost-effective solution for large-scale genomic studies.
48-sample BeadChip provides scalability advantages over 24-sample, Infinium Global Screening Array v3.0
Infinium Global Screening Array v4.0 includes environmentally friendly, formamide-free reagents
Infinium Global Screening Array v4.0 requires 100 ng of input DNA, requiring only half the input amount required for the Infinium Global Screening Array v3.0

Key features
Approximately 650K markers that span the human genome
48-sample BeadChip built for high-throughput laboratories
Automated, scalable workflow with a 2–2.5-day turnaround time
50K marker custom add-on capacity enables flexibility
BeadChips built on Infinium EX format compatible with powerful liquid handling instruments running most advanced software

Optimized global content
Genome-wide content in v4.0 includes variants with established disease associations, relevant pharmacogenomics markers, and curated exonic content derived from ClinVar, NHGRI, PharmGKB, and ExAC databases.

Widely adopted
Over 30 million samples of the Global Screening Array have been ordered by researchers, healthcare networks, consumer genomics companies, and genomic service providers.

Broad applications
Precision medicine research initiatives around the world use the Global Screening Array to study disease risk, stratify samples, and incentivize participation across a large variety of clinical applications.

What accessories do I need?
Standard Infinium accessories (e.g., Te-Flow chamber, hybridization oven, etc.)

What is needed to implement the Infinium EX genotyping workflow?
You will need the following products:
iScan System
Infinium EX array kit, such as the Global Screening Array-48 v4.0 kit
Infinium Automated Pipetting System with ILASS, to be used for post-amplification steps
Infinium Amplification System (Optional), to be used to automate pre-PCR steps (WGA)
Infinium EX/XT starter kit

What are the advantages of the Infinium EX platform?
Throughput:
The ability to run 48 samples per BeadChip on Infinium Global Screening Array-48 Kit and scale up to 11,520 samples per week
iScan System with Infinium liquid handler instruments can scale up to hundreds of thousands of samples per year
Automation: Illumina Lab Automation Software Solution (ILASS) guides the user through the steps of the workflow via an intuitive user interface and provides on-deck validation, meaning the consumables loaded on the liquid handling robots are verified prior to use regardless of whether the customer is using LIMS. Real-time integration with cloud-based Clarity LIMS supports compliance with eSignature capability, audit trails, reagent and lot tracking, preset protocols, and privacy and security controls, which is critical for high-throughput customers.

How does the workflow for Infinium EX arrays differ from previous Infinium workflows?
Whole-genome amplification step is 3 hr for Infinium EX compared with 24 hr for legacy Infinium workflows, reducing total workflow time by 20%
Input DNA required for Infinium EX genotyping workflow is 100 ng compared with 200 ng for legacy workflows
Reagents are EH&S-friendly and formamide free
ILASS provides an improved UI and support experience
Updated automation and software allow integration with cloud-based analysis

How does the content differ between the Infinium Global Screening Array-48 v4.0 and Infinium Global Clinical Research Array-24 v1.0 content?
Both arrays feature a multiethnic genome-wide backbone with content for population studies, variant screening, and precision medicine research. In addition to this, Infinium Global Clinical Research Array-24 v1.0 covers additional clinical research markers from ACMG 73 and gnomAD exome to increase coverage of underrepresented populations.

Applications
The Infinium Global Screening Array-48 4 is a powerful, efficient, and cost-effective BeadChip for population-scale genomic studies. Designed for an extensive range of applications, users can leverage flexible, customizable options while enjoying intuitive workflows.

Example workflow
Genotyping
Use cutting-edge genotyping techniques to explore a broad range of genetic variants and gain insight into disease etiology and traits on a molecular level.
iScan
The iScan microarray scanner supports high-throughput BeadChip processing, scanning hundreds to thousands of samples quickly and accurately.
DRAGEN Array
DRAGEN Array provides accurate, comprehensive and efficient secondary analysis for Infinium microarrays.
GenomeStudio Software
GenomeStudio software provides an integrated platform for data analysis of microarray-based genotyping assays, with a user-friendly graphical interface.

Resources
Introducing the Infinium EX platform
The Infinium EX platform enables more comprehensive coverage of the genome and supports higher volume sample processing. The workflow includes components designed to work seamlessly together including EX BeadChips with expertly selected content, advanced automation, and DRAGEN Array secondary analysis software. Learn more about the accuracy, scalability, cost-effectiveness, and efficient workflow of the Infinium EX platform.
Infinium Global Screening Array-48 v4.0 Kit (48 samples)
20065217
The Global Screening Array-48 v4.0 Kit, built on proven Infinium technology, offers exceptional coverage of key genome-wide clinical content, and provides a cost-effective and highly scalable workflow to support population-scale clinical research studies. View less
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Infinium Global Screening Array-48 v4.0 Kit (96 samples)
20068344
Infinium Global Screening Array-48 v4.0 Kit (1152 samples)
20068345
The Global Screening Array-48 v4.0 Kit, built on proven Infinium technology, offers exceptional coverage of key genome-wide clinical content, and provides a cost-effective and highly scalable workflow to support population-scale clinical research studies View less
Infinium Global Screening Array-48+ v4.0 Kit (48 Samples)
20068360
Infinium Global Screening Array-48+ v4.0 Kit (96 Samples)
20068361
Infinium Global Screening Array-48+ v4.0 Kit (1152 Samples)
20068362
Infinium Automated Pipetting System with ILASS
20051293
This package supports customers who want to automate their Infinium processing using ILASS control software. It includes a cloud-based Clarity LIMS- ready Tecan Freedom EVO 150cm liquid handler with RoMA ARM equipped to run Post-AMP Infinium Assay protocols, robotic accessories and Robot Control Software. Training is included. Cloud-based Clarity LIMS sold separately. NOTE: Only certain Infinium Assay Protocols can be run on ILASS. View less
Infinium Amplification System
20064466
This package supports customers who want to automate their Pre-AMP Infinium processing. It includes a cloud-based Clarity LIMS-ready Hamilton Star liquid handler equipped to run Pre-AMP Infinium Assay protocols, robotic accessories and ILASS control software. Training is included. Cloud-based Clarity LIMS sold separately. NOTE: Only certain Infinium Assay Protocols can be run on ILASS. View less
Infinium EX/XT Starter Kit (24 Beadchip) 220V
20031992
Infinium EX/XT Starter Kit (24 Beadchip) 220V View less
Infinium EX/XT Starter Kit (24 Beadchip) 110V
20031915
Infinium EX/XT Starter Kit (24 Beadchip) 110V View less
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Specifications

General

Sample throughput	~11,520
Number of samples	48
Number of markers	~650K
Automation capability	Automated array loader, Liquid handling robot(s)
Input quantity	100 ng
Instruments	iScan System
Method	Genome-wide genotyping array
Nucleic acid type	DNA
Number of markers	650,321 markers and 50,000 custom marker capacity
Number of samples	48 samples/array
Sample throughput	11,520 samples/week max throughput per iScan System. Throughput and scan times will vary based on system configuration.
Specialized sample types	Blood
Species category	Human
Technology	Microarray
Variant class	Single nucleotide polymorphisms (SNPs), Structural variants, Insertions-deletions (indels), Copy number variants (CNVs)

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Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
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