Overview
The Infinium MethylationEPIC v2.0 kit is a genome-wide methylation analysis tool targeting ~930K unique methylation sites in the most biologically significant regions of the human methylome.
Quantitative interrogation of CpGs at single-nucleotide resolution, with accurate and precise methylation measurements independent of read depth
Primary analysis and quality control with the GenomeStudio Methylation Module
Updated content guided by expert evaluations of EPIC v1.0
Cost-effective analysis
Genome-wide coverage at a relative affordable cost enables scalable discovery of powerful biological insights into disease mechanisms.
Trusted by epigenetics researchers
Illumina methylation BeadChips have powered > 10 years of groundbreaking research, with most published epigenome-wide association studies (EWAS) to date completed on MethylationEPIC or its predecessor. Harness methylation data in data repositories like the Gene Expression Omnibus (GEO) or The Cancer Genome Atlas (TCGA).
FFPE compatible
In addition to whole blood, Methylation EPICv2.0 is also compatible with FFPE sample types, enabling studies to be completed on large biorepositories of tumors.
Applications
Infinium MethylationEPIC v2.0 BeadChip is a robust microarray that enables discovery of methylation-based biomarkers for research applications in cancer, genetic diseases, aging, and molecular epidemiology.
Example workflow
Infinium MethylationEPIC v2.0 Kit
Infinium HD Methylation Assay
iScan System
Infinium Automation Option Packages
Methylation Array Data Analysis Tips
Related applications and methods
DNA methylation analysis
Genome-wide methylation profiling studies with microarray and NGS technologies can provide novel insights into the functional impact of methylation.
Complex and genetic disease research
Comprehensive array and next-generation sequencing solutions to accelerate research of various genetic complex diseases.
Cancer epigenetics
Explore the benefits of next-generation sequencing and microarrays for analyzing altered methylation patterns and other epigenetic changes in cancer.
Infinium MethylationEPIC v2.0 coverage of genomic regions
New and enhanced content enables future epigenetic discoveries.
Dense coverage of CpG islands
CpG islands and exons that were covered insufficiently on the Infinium MethylationEPIC v1.0 BeadChip are covered thoroughly with additional probes.
Robust data with FFPE samples
FFPE tissue samples show robust performance with a modified version of the Infinium Methylation HD Assay. For precious samples and optimal sample integrity, the Infinium FFPE QC and DNA Restoration Kits are recommended.
High backwards compatibility with previous BeadChips
The Infinium MethylationEPIC v2.0 BeadChip builds upon the existing CpG backbones of the Infinium MethylationEPIC v1.0 and HumanMethylation450 BeadChips.
Inf MethylationEPIC V2.0 Kit (8 Spl)
20087706
Includes one, 8-sample BeadChip and reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 8 DNA samples. Requires 250 ng DNA for input. Each kit is processed as a single batch. Purchase bisulfite conversion kits separately. View less
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Inf MethylationEPIC V2.0 Kit (16 Spl)
20087707
Includes two, 8-sample BeadChips and reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 16 DNA samples. Requires 250 ng DNA for input. Each kit is processed as a single batch. Purchase bisulfite conversion kits separately. View less
Inf MethylationEPIC V2.0 Kit (32 Spl)
20087708
Includes four, 8-sample BeadChips and reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 32 DNA samples. Requires 250 ng DNA for input. Each kit is processed as a single batch. Purchase bisulfite conversion kits separately. View less
Inf MethylationEPIC V2.0 Kit (96 Spl)
20087709
Includes 12, 8-sample BeadChips and reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 96 DNA samples. Requires 250 ng DNA for input. Each kit is processed as a single batch. Purchase bisulfite conversion kits separately. View less
Inf MethylationEPIC-8+ v2.0 Kit (16 Spl)
20097750
Semi-custom EPIC v2 containing a custom selection of 3,000-10,000 attempted beadtypes on top of EPIC v2. Kit contains 2 beadchips with reagents for processing 16 samples. View less
Inf MethylationEPIC-8+ v2.0 Kit (32 Spl)
20097751
Semi-custom EPIC v2 containing a custom selection of 3,000-10,000 attempted beadtypes on top of EPIC v2. Kit contains 4 beadchips with reagents for processing 32 samples. View less
Inf MethylationEPIC-8+ v2.0 Kit (96 Spl)
20097752
Semi-custom EPIC v2 containing a custom selection of 3,000-10,000 attempted beadtypes on top of EPIC v2. Kit contains 12 beadchips with reagents for processing 96 samples. View less
Infinium® Assay: An Introduction – Customer Site
20015273
Three-day, hands-on instruction at customer site to familiarize users with the essential steps in the Infinium protocol. Course provides hands-on training in sample and BeadChip preparation, sample scanning using the iScan System, and primary data evaluation and analysis using array analysis software. View less
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How does the Illumina MethylationEPIC 2.0 Kit work?
The Infinium Methylation EPIC v2.0 BeadChip Kit leverages powerful Infinium chemistry to detect cytosine methylation at CpG islands based on highly multiplexed genotyping of bisulfite-converted genomic DNA. Learn more about quantitative array-based methylation measurement .
This kit uses the Illumina Methylation Assay, a microarray technology that provides quantitative methylation measurement at the single-CpG-site level, powering research that examines the biological role of DNA methylation in normal and diseased cells. Learn more about the Illumina Methylation Assay .
How does Infinium MethylationEPIC v2.0 BeadChip Kit differ from EPIC v1.0?
The Infinium MethylationEPIC v2.0 BeadChip Kit contains 186K new probes that target known enhancers, super-enhancers, CTCF-binding sites, and open regions of chromatin associated with primary tumors identified by ATAC-Seq and ChIP-seq experiments. Learn about additional improvements in the Infinium MethylationEPIC v2.0 data sheet .
How do I analyze the Infinium MethylationEPIC v2.0 BeadChip array data?
Illumina offers user friendly tools to analyze Infinium controls built into the MethylationEPIC BeadChip. For more information visit the Methylation Array Data Analysis Tips Page .
Which bisulfite conversion kit should I use with the MethylationEPIC v2.0 Kit?
The Zymo EZ DNA Methylation Lightning Kit is the recommended bisulfite conversion kit for the Infinium workflow. Third party bisulfite conversion kits must be purchased separately. Learn more about validated bisulfite conversion kits for Infinium Methylation BeadChips .
How long does it take to scan a MethylationEPIC v2.0 array on the iScan System?
The scan takes ~18–37 minutes per BeadChip.
Are the Infinium MethylationEPIC v1.0 and HumanMethylation450 BeadChip kits discontinued?
Yes, the Infinium MethylationEPIC v1.0 and HumanMethylation450 BeadChip kits have been discontinued. The Infinium MethylationEPIC v2.0 Kit , built upon the same reliable Infinium chemistry foundation, offers enhanced, expert-selected content and is the recommended replacement for both kits.
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