Illumina, HLA-HS-1004-24, oncoReveal Core LBx 24 Rxn

Name: oncoReveal Core LBx 24 Rxn
Brand: Illumina
SKU: HLA-HS-1004-24

104 gene (24 sample) liquid biopsy cfDNA panel on SLIMamp™ workflow

Catalog Number: HLA-HS-1004-24

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Category

NGS Library Preparation Kits

Pack Size24 reactions

TagsSequencing kits Library preparation kits

Description

Pillar oncoReveal Core LBx Panel
Robust cfDNA liquid biopsy NGS assay, interrogating 104 genes from plasma across multiple solid tumor types.
Pillar oncoReveal Core LBx Panel Data sheet PDF < 1 MB
Data sheet PDF < 1 MB
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Overview
The Pillar oncoReveal Core LBx Panel is a robust liquid biopsy NGS assay that interrogates 466 targets across 104 genes relevant to multiple solid tumor types using cell-free DNA (cfDNA) isolated from plasma samples.

Key features
Access a rapid workflow to go from sample to report in under 48 hours
Achieve variant detection as low as 0.1% VAF without UIDs even with limited DNA input or poor sample quality
Improve lab efficiency and reduce “no calls"
The panel is designed for cfDNA from plasma and can detect four types of variants: single nucleotide variants (SNVs), small insertion/deletion (indel) variants, copy number amplification (CNA), and microsatellite instability (MSI).
The assay uses proprietary Stem-Loop Inhibition-Mediated amplification (SLIMamp) technology, a tiled amplicon-based library prep chemistry for efficient single-tube target enrichment.
The workflow allows labs to maintain control of samples and results with single-tube, tiled amplification that can be performed in-house by any NGS lab.

Applications
The Pillar oncoReveal Core LBx Panel analyzes cfDNA from plasma in under 10 hours with approximately 3 hours of hands-on time.

Example workflow
Pillar oncoReveal Core LBx Panel
NextSeq 550 System
NextSeq 550Dx Instrument (RUO mode)
Pillar PiVAT
Illumina Connected Insights

Related applications and methods
Liquid biopsy for cancer biomarker research
Researchers can use liquid biopsy NGS assays to detect and characterize tumor-derived biomarkers present in the blood of individuals with cancer.
Advancing cancer research through NGS
Our sequencing and microarray technologies support a broad range of cancer genomics research applications, from DNA to RNA analysis, epigenetics, and more.

Figures
Gene List
Pillar oncoReveal Core LBx Panel includes 446 amplicons across 104 driver genes.
Panel Specifications
Pillar oncoReveal Core LBx Panel specifications for cfDNA interrogation from blood plasma.
oncoReveal Core LBx 24 Rxn
HLA-HS-1004-24
104 gene (24 sample) liquid biopsy cfDNA panel on SLIMamp™ workflow View less
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Pillar Biosciences LBx Indexing Kit A
IDX-PI-1013-96
Index kit for oncoReveal cfDNA/cfRNA panels View less
Pillar Biosciences LBx Indexing Kit B
IDX-PI-1014-96
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Specifications

General

Assay time	48 hr from sample to report
Hands-on time	~3 hr
Input quantity	10–30 ng cfDNA
Cancer type	Pan-cancer, Solid tumor
Content specifications	446 amplicons across 104 genes
Description	The Pillar oncoReveal Core LBx Panel is a robust cfDNA liquid biopsy NGS assay that interrogates 446 targets from 104 genes of interest across multiple solid tumor types.
Instruments	NextSeq 550 System , NextSeq 550Dx in Research Mode
Mechanism of action	Multiplex PCR using tiled amplicon
Method	Targeted DNA sequencing , Amplicon sequencing
Nucleic acid type	DNA
Number of amplicons	Pool 1: 446 amplicons
Number of reactions	24 reactions per kit
On-target reads	≥ 90%
Specialized sample types	Cell-free DNA
Species category	Human
Target insert size	80 bp
Technology	Sequencing
Uniformity	≥ 90%
Variant class	Single nucleotide variants (SNVs), Insertions-deletions (indels), Copy number variants (CNVs), Blood microsatellite instability (bMSI)

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Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
All quotations are subject to final confirmation, including product availability, lead time, batch information, shipping cost, and applicable export or handling requirements.
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