Illumina, HLA-HS-1005-24, oncoReveal Fusion LBx 24 Rxn

Name: oncoReveal Fusion LBx 24 Rxn
Brand: Illumina
SKU: HLA-HS-1005-24

18 gene (24 sample) liquid biopsy cfRNA panel on SLIMamp™ workflow

Catalog Number: HLA-HS-1005-24

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Category

NGS Library Preparation Kits

Pack Size24 reactions

TagsSequencing kits Library preparation kits

Description

Pillar oncoReveal Fusion LBx Panel
Robust cfRNA liquid biopsy NGS assay interrogating 83 fusions from plasma across multiple solid tumor types.
Pillar oncoReveal Fusion LBx Panel Data sheet PDF < 1 MB
Data sheet PDF < 1 MB
Assay time
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Overview
The Pillar oncoReveal Fusion LBx Panel is a robust NGS assay designed to interrogate 18 driver genes and over 80 partners relevant across multiple solid tumor types using cell-free RNA (cfRNA) isolated from plasma.

Key features
Rely on a rapid workflow going from sample to report within 48 hours
Achieve sensitive and robust fusion detection without UIDs even with limited RNA input or poor sample quality
Improve lab efficiency and reduce “no calls”
This focused panel can detect gene rearrangements from fusion transcripts (cfRNA) isolated from plasma.
The assay uses proprietary Stem-Loop Inhibition-Mediated amplification (SLIMamp) technology, a tiled amplicon-based library prep chemistry for efficient single-tube target enrichment.
The workflow allows labs to maintain control of samples and results with single-tube, tiled amplification that can be performed in-house by any NGS lab.

Applications
Pillar oncoReveal Fusion LBx Panel analyzes multiple solid tumor types using cfRNA isolated from plasma in under 10 hours with approximately 3 hours of hands-on time.

Example workflow
Pillar oncoReveal Fusion LBx Panel
MiSeq i100 Series
MiSeqDx Instrument (in RUO mode)
NextSeq 550 System
NextSeq 550Dx Instrument (in RUO mode)
Illumina Connected Insights

Related applications and methods
Liquid biopsy for cancer biomarker research
Researchers can use liquid biopsy NGS assays to detect and characterize tumor-derived biomarkers present in the blood of individuals with cancer.
Advancing cancer research through NGS
Our sequencing and microarray technologies support a broad range of cancer genomics research applications, from DNA to RNA analysis, epigenetics, and more.
Detecting changes in the cancer transcriptome
Detect cancer gene expression and transcriptome changes and identify novel cancer transcripts with RNA next-generation sequencing (RNA-Seq).

Figures
Gene List
Pillar oncoReveal Fusion LBx Panel includes 18 driver genes and 83 partner genes.
Panel Specifications
Pillar oncoReveal Fusion LBx Panel specifications for cfRNA interrogation from blood plasma.
oncoReveal Fusion LBx 24 Rxn
HLA-HS-1005-24
18 gene (24 sample) liquid biopsy cfRNA panel on SLIMamp™ workflow View less
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Pillar Biosciences LBx Indexing Kit A
IDX-PI-1013-96
Index kit for oncoReveal cfDNA/cfRNA panels View less
Pillar Biosciences LBx Indexing Kit B
IDX-PI-1014-96
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Specifications

General

Assay time	48 hr from sample to report
Hands-on time	~3 hr
Input quantity	10–30 ng cfRNA
Cancer type	Pan-cancer, Solid tumor
Content specifications	18 driver genes and 83 partners
Description	The Pillar oncoReveal Fusion LBx Panel is a robust cfRNA liquid biopsy NGS assay that interrogates fusion transcripts from 18 driver genes with more than 80 partners relevant across multiple solid tumor types.
Instruments	MiSeqDx in Research Mode , NextSeq 550Dx in Research Mode , MiSeq i100 System
Mechanism of action	Multiplex PCR using tiled amplicon
Method	Amplicon sequencing , Targeted RNA sequencing
Nucleic acid type	RNA
Number of amplicons	Pool 1: 83 amplicons
Number of reactions	24 reactions per kit
Specialized sample types	Cell-free RNA
Species category	Human
Strand specificity	Non-stranded
Target insert size	80 bp
Technology	Sequencing
Variant class	Gene fusions

Ordering

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Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
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