Description
Overview
The Infinium OncoArray-500K contains 500,000 SNPs with a genome-wide backbone of 250,000 tag SNPs. Additional SNPs include genetic variants associated with breast, colorectal, lung, ovarian, and prostate cancers plus SNPs covering ancestry, quantitative traits, pharmacogenetics, and fine-mapping of common cancer susceptibility loci. To support additional research requirements, the Infinium OncoArray-500K can be tailored to incorporate up to 120,000 custom beadtypes.*
The Infinium OncoArray-500K was developed in collaboration with leading experts from the OncoArray consortium†, and draws on many of the features of the successful Collaborative Oncological Gene-environment Study (iCOGS) array1. Designed with candidate SNPs identified by the consortium, the OncoArray provides a cost-effective means to assess candidate variants potentially associated with cancer risk.
The Infinium OncoArray-500K uses a 24-sample high-throughput screening (HTS) BeadChip to enable maximum throughput, productivity, and genotyping accuracy. Using the proven iScan System, the Infinium OncoArray-500K is designed to combine affordability with high-density content, providing insight into the relationship between gene variants and cancer predisposition in five of the most prevalent cancers.
* For additional information about custom add-on content, contact your Illumina account manager or sales specialist .
View Manifest (Array Content) Files
Example workflow
Human Genotyping
DesignStudio Assay Design Tool
iScan System
Related applications and methods
Germline Mutation Detection in Cancer
Identify germline mutations that predispose individuals to cancer using next-generation sequencing and microarrays.
Cancer panels
Access a broad range of fixed and custom next-generation sequencing panels targeting known cancer-related gene variants.
Microarray Data Analysis & Experimental Design
Find microarray data analysis tools and tips to help you to visualize and analyze microarray data and facilitate data analysis for large experiments.