Description
General description
Interleukin-17F (IL-17F) is a cytokine that belongs to the IL-17 family and is primarily produced by Th17 cells and other immune cells. It shares structural similarities with IL-17A and plays a role in promoting inflammatory responses, particularly in the context of autoimmune diseases and chronic inflammation. IL-17F is involved in the recruitment of neutrophils and the enhancement of pro-inflammatory cytokine production, contributing to the body′s defense against pathogens as well as the pathogenesis of various inflammatory conditions.
Application
Inflammatory Disease / Immune Response / Autoimmune Disease
Features and Benefits
Detect the Undectable: Detects IL-17F at concentrations as low as 200 fg/mL, enabling precise quantification of low-abundance cytokines in human plasma and serum.
Wide Dynamic Range: Standard curve spans 100-100,000 fg/mL, supporting both basal and elevated IL-17F levels in diverse sample types.
Advance Th17 Pathway Research: IL-17F is a critical cytokine in autoimmune and inflammatory diseases such as asthma, psoriasis, and IBD. This assay supports mechanistic studies and therapeutic development.
Enable Early Biomarker Discovery: Detect subclinical cytokine shifts with high sensitivity, ideal for identifying early disease markers and monitoring immune responses.
Packaging
96 well assay
Analysis Note
Sensitivity: LLOQ 200 fg/mL* (SMCxPRO® Instrument)
Standard Curve Range: 100-100,000 fg/mL
Intra-assay CV: Inter-assay CV: Linearity: Serum: 99% Plasma: 101%
Recovery: Serum: 94% Plasma: 105%
*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.
Other Notes
Although IL-17F was detectable in non-human primate samples, the assay has not been verified for these species.
Legal Information
FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany
SMC is a registered trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
