Description
General description
Interleukin-5 (IL-5) is a cytokine primarily produced by activated T cells, particularly Th2 cells, and plays a pivotal role in the regulation of eosinophil differentiation, activation, and survival. It is essential for the immune response against parasitic infections and is also implicated in allergic reactions and asthma, where elevated levels of IL-5 contribute to eosinophilic inflammation. Understanding IL-5′s functions is crucial for developing targeted therapies for various allergic and inflammatory diseases.
Application
Inflammatory Disease / Immune Response / Autoimmune Disease
Features and Benefits
Ultra-High Sensitivity: This IL-5 assay kit offers exceptional sensitivity, allowing researchers to detect low concentrations of IL-5 in biological samples, which is crucial for studying subtle changes in immune responses.
Accurate Quantification: With precise measurement capabilities, the kit enables accurate quantification of IL-5 levels, facilitating reliable data collection for research on allergic diseases, asthma, and eosinophilic disorders.
Cost-Effective Research Tool: By enabling the early detection of IL-5 and reducing the need for extensive follow-up studies, this high-sensitivity assay kit can help optimize research budgets while providing valuable insights into immune function.
SMC Technology Advantage: The incorporation of SMC technology allows for unprecedented sensitivity and accuracy in IL-5 detection, making it a game-changer for researchers aiming to uncover critical insights into immune system dynamics.
Packaging
96 well assay
Analysis Note
Sensitivity: LLOQ 40 fg/mL* (SMCxPRO® Instrument)
Standard Curve Range: 10-50,000 fg/mL
Intra-assay CV: Inter-assay CV: Linearity: Serum: 106% Plasma: 111%
Recovery: Serum: 98% Plasma: 100%
*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.
Other Notes
Although IL-5 was detectable in non-human primate, canine, rat, and mouse plasma, the assay has not been verified for these species.
Legal Information
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany
FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany
SMC is a registered trademark of Singulex
Disclaimer
Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
