Merck, 03-0177-00, SMC® Human IL-17A/F Heterodimer High Sensitivity Immunoassay Kit

General description
Interleukin-17A/F (IL-17A/F) is a heterodimeric cytokine formed by the combination of IL-17A and IL-17F subunits, both of which are produced primarily by Th17 cells. This cytokine plays a significant role in mediating inflammatory responses and is involved in the recruitment of neutrophils and other immune cells to sites of inflammation. IL-17A/F is implicated in various autoimmune diseases and chronic inflammatory conditions, highlighting its potential as a therapeutic target for managing such disorders.
Application
Inflammatory Disease / Immune Response / Autoimmune Disease
Features and Benefits
Specific Detection of IL-17A/F Heterodimer: Enables accurate quantification of the biologically distinct IL-17A/F complex, which plays a unique role in Th17-mediated inflammation and autoimmune disease.
Ultra-Sensitive Quantification via SMC®Technology: Supports early detection of immune activation, especially in diseases where IL-17A/F is present at low levels, such as psoriasis, multiple sclerosis, and IBD.
Verified for Human Serum and Plasma: Demonstrates high recovery rates (88–101%) in spiked human samples.

Packaging
96 well assay
Analysis Note
Sensitivity: LLOQ 2,340 fg/mL* (SMCxPRO® Instrument)
Standard Curve Range: 590-600,000 fg/mL
Intra-assay CV: Inter-assay CV: Linearity: Serum: 106% Plasma: 111%
Recovery: Serum: 101% Plasma: 88%
*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.
Other Notes
Although IL-17A/F Heterodimer was detectable in non-human primates, monkey and canine samples, the assay has not been verified for these species.
Legal Information
SMC is a registered trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.